DegronMD

Uniprot ID: Q12872

Source protein: Splicing factor, suppressor of white-apricot homolog

Source gene: SFSWAP

Class: DEG_SPOP_SBC_1

Location: 433:437

E3 ligase: SPOP

DEGRON score: 0.9872

ASA_SCORE: 83.7

COIL: 0.9464

CONS_SCORE: 0.2404

DSS_SCORE: 0.6521

HELIX: 0.024

FCONS_SCORE: 0.7499

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E428D	TCGA-AA-3715	COAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.E428D	DO8018	COAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.G432R	TCGA-D3-A5GU	SKCM	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.G432R	TCGA-FI-A2D0	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.G432R	DO47584	SKCM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.G432R	DO43891	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.G432E	TCGA-D3-A5GU	SKCM	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.G432E	DO47584	SKCM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.A433V	TCGA-DI-A1BU	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.5825
p.A433V	DO42023	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.5825
p.S441I	DO229015	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2222
p.V446M	SIDM01943	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.0833
p.E428Q	SIDM00669	Pancreatic Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.E428Q	ACH-000094	Pancreatic Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1944
p.E428Q	HPAF-II	pancreas	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons