DegronMD

Uniprot ID: Q5T2D2

Source protein: Trem-like transcript 2 protein

Source gene: TREML2

Class: DEG_SPOP_SBC_1

Location: 194:198

E3 ligase: SPOP

DEGRON score: 0.8687

ASA_SCORE: 82.62

COIL: 0.9016

CONS_SCORE: 0.5462

DSS_SCORE: 0.6127

HELIX: 0.0224

FCONS_SCORE: 1.0267

RIG_SCORE: 0.6878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G189V	TCGA-12-0775	GBM	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.G189V	DO14133	GBM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.S196R	TCGA-49-AAR0	LUAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.7427
p.S196R	DO218917	LUAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7427
p.P202H	TCGA-BA-A6DA	HNSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.2222
p.P202H	DO44448	HNSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2222
p.S199R	TCGA-BA-A6DA	HNSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S199R	DO44448	HNSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.R204K	TCGA-GN-A262	SKCM	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1667
p.R204K	DO231782	LINC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.R204K	DO37515	SKCM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.A194D	DO228976	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7793
p.T198N	DO229028	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7055
p.T193A	SIDM01169	Ovarian Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.T193A	SIDM01716	Non-Cancerous	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.T193A	SIDM00175	Melanoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.T193A	SIDM01772	Mesothelioma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.T193A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.M206T	SIDM01608	Endometrial Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.M206T	ACH-000990	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1111
p.S186C	ACH-001611	Brain Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons