DegronMD - Q12872(SFSWAP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A381V	TCGA-A5-A0G2	UCEC	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	TCGA-AP-A051	UCEC	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	DO227987	COCA	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	DO41235	UCEC	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	DO42673	UCEC	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	SIDM00217	Colorectal Carcinoma	GDSC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	ACH-000999	Colon/Colorectal Cancer	CCLE	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.A381V	SNU-1040	large intestine	COSMIC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1389
p.E428D	TCGA-AA-3715	COAD	TCGA	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944
p.E428D	DO8018	COAD	ICGC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944
p.A327T	TCGA-AA-3833	COAD	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1111
p.A327T	DO9796	COAD	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1111
p.R331C	TCGA-AG-A002	READ	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	TCGA-AP-A1DV	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	TCGA-FS-A1ZA	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	TCGA-FW-A3R5	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	DO218874	SKCA	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	DO37551	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	DO37406	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331C	DO43186	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331H	TCGA-AP-A1DK	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331H	DO42033	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.T339S	TCGA-AR-A256	BRCA	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6005
p.T339S	DO4155	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6005
p.R331S	TCGA-CA-6717	COAD	TCGA	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.R331S	DO8264	COAD	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.G432R	TCGA-D3-A5GU	SKCM	TCGA	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.G432R	TCGA-FI-A2D0	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.G432R	DO47584	SKCM	ICGC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.G432R	DO43891	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.G432E	TCGA-D3-A5GU	SKCM	TCGA	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.G432E	DO47584	SKCM	ICGC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.3056
p.P382S	TCGA-DI-A1BU	UCEC	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1667
p.P382S	DO42023	UCEC	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1667
p.A433V	TCGA-DI-A1BU	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.5825
p.A433V	DO42023	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.5825
p.P384S	TCGA-ER-A195	SKCM	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2222
p.P384S	DO47712	SKCM	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2222
p.G386E	TCGA-EW-A1J5	BRCA	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2778
p.G386E	DO6144	BRCA	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2778
p.G386V	TCGA-IF-A4AK	SARC	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2778
p.G386V	DO220165	SARC	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2778
p.T395S	TCGA-QQ-A8VF	SARC	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation altering degron motif	0.6005
p.T395S	DO220258	SARC	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation altering degron motif	0.6005
p.V389M	TCGA-VQ-AA64	STAD	TCGA	DVTTYYSTLP	CBL_PTK	388:397	Mutation altering degron motif	0.6097
p.V389M	DO222381	STAD	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation altering degron motif	0.6097
p.T341A	DO230309	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.A345S	DO233128	GACA	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.C816Y	DO233207	GACA	ICGC	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.1944
p.V400L	DO228948	LICA	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.25
p.G399V	DO228948	LICA	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.2778
p.S441I	DO229015	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2222
p.A335S	DO229028	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7588
p.A837V	DO232846	NACA	ICGC	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.0833
p.S394N	DO232224	PBCA	ICGC	DVTTYYSTLP	CBL_PTK	388:397	Mutation altering degron motif	0.7069
p.R812C	DO47841	STAD	ICGC	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.0833
p.R833C	DO41020	UCEC	ICGC	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.1944
p.A820V	DO42673	UCEC	ICGC	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.3056
p.V446M	SIDM01943	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0833
p.I387V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.3056
p.I387V	ACH-000665	Lung Cancer	CCLE	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.3056
p.I387V	SK-MES-1	lung	COSMIC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.3056
p.E428Q	SIDM00669	Pancreatic Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944
p.E428Q	ACH-000094	Pancreatic Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944
p.E428Q	HPAF-II	pancreas	COSMIC	ATSTT	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944
p.S405F	SIDM00351	Oral Cavity Carcinoma	GDSC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1111
p.S405F	ACH-002029	Head and Neck Cancer	CCLE	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1111
p.S405F	SAS	upper aerodigestive tract	COSMIC	DVTTYYSTLP	CBL_PTK	388:397	Mutation rewiring degron network	0.1111
p.A348V	SIDM00673	Breast Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0833
p.R830H	ACH-000491	Colon/Colorectal Cancer	CCLE	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.2778
p.R830C	ACH-000990	Endometrial/Uterine Cancer	CCLE	EERSVPTA	DEG_COP1_1	821:828	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SFSWAP

UniProt ID: Q12872

Entrez ID: 6433

Protein name: Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SFSWAP in