DegronMD

Uniprot ID: Q12872

Source protein: Splicing factor, suppressor of white-apricot homolog

Source gene: SFSWAP

Class: DEG_SPOP_SBC_1

Location: 335:339

E3 ligase: SPOP

DEGRON score: 0.9423

ASA_SCORE: 86.32

COIL: 0.854

CONS_SCORE: 0.2831

DSS_SCORE: 0.6272

HELIX: 0.1428

FCONS_SCORE: 0.879

RIG_SCORE: 0.5789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A327T	TCGA-AA-3833	COAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.1111
p.A327T	DO9796	COAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.1111
p.R331C	TCGA-AG-A002	READ	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	TCGA-AP-A1DV	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	TCGA-FS-A1ZA	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	TCGA-FW-A3R5	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	DO218874	SKCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	DO37551	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	DO37406	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331C	DO43186	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331H	TCGA-AP-A1DK	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331H	DO42033	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.T339S	TCGA-AR-A256	BRCA	TCGA	ADSST	DEG_SPOP_SBC_1	0.6005
p.T339S	DO4155	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.6005
p.R331S	TCGA-CA-6717	COAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.R331S	DO8264	COAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.T341A	DO230309	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.2778
p.A345S	DO233128	GACA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.A335S	DO229028	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	0.7588
p.A348V	SIDM00673	Breast Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons