DegronMD

Uniprot ID: Q14005

Source protein: Pro-interleukin-16 [Cleaved into: Interleukin-16

Source gene: IL16

Class: DEG_SPOP_SBC_1

Location: 774:778

E3 ligase: SPOP

DEGRON score: 0.9891

ASA_SCORE: 78.98

COIL: 0.888

CONS_SCORE: 0.4807

DSS_SCORE: 0.6108

HELIX: 0.0902

FCONS_SCORE: 0.9633

RIG_SCORE: 0.6676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P783T	TCGA-44-2655	LUAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.1944
p.P783H	TCGA-44-2655	LUAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.1944
p.P783A	TCGA-61-2095	OV	TCGA	ADSST	DEG_SPOP_SBC_1	0.1944
p.A764T	TCGA-CQ-5332	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	0.0556
p.A764T	SIDM02015	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.0556
p.P784S	TCGA-EE-A181	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	0.1667
p.A786T	TCGA-EL-A3CM	THCA	TCGA	ADSST	DEG_SPOP_SBC_1	0.1111
p.D775G	SIDM00846	Cervical Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons