DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: DEG_SPOP_SBC_1

Location: 1481:1485

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 78.3

COIL: 0.8608

CONS_SCORE: 0.3397

DSS_SCORE: 0.595

HELIX: 0.1142

FCONS_SCORE: 0.9852

RIG_SCORE: 0.6035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1487C	TCGA-92-8063	LUSC	TCGA	ADSST	DEG_SPOP_SBC_1	0.2778
p.S1494Y	TCGA-FU-A3TX	CESC	TCGA	ADSST	DEG_SPOP_SBC_1	0.0833
p.G1492R	TCGA-FV-A23B	LIHC	TCGA	ADSST	DEG_SPOP_SBC_1	0.1389
p.H1472R	DO23496	LINC	ICGC	ADSST	DEG_SPOP_SBC_1	0.0833
p.H1472R	DO45053	LINC	ICGC	ADSST	DEG_SPOP_SBC_1	0.0833
p.A1481V	ACH-000983	Leukemia	CCLE	ADSST	DEG_SPOP_SBC_1	0.5825
p.A1481V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	ADSST	DEG_SPOP_SBC_1	0.5825
p.S1495C	PANC-02-03	pancreas	COSMIC	ADSST	DEG_SPOP_SBC_1	0.0556
p.Q1471H	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	ADSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons