DegronMD - P38398(BRCA1)

FUNCTION: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. View more >>

GO - Biological processes (BP): cellular response to DNA damage stimulus [GO:0006974]; cellular response to indole-3-methanol [GO:0071681]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; centrosome cycle [GO:0007098]; chordate embryonic development [GO:0043009]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fatty acid biosynthetic process [GO:0006633]; histone H2A K63-linked deubiquitination [GO:0070537]; histone H2A monoubiquitination [GO:0035518]; homologous recombination [GO:0035825]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cell cycle [GO:0045786]; negative regulation of centriole replication [GO:0046600]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of histone acetylation [GO:0035067]; negative regulation of histone H3-K4 methylation [GO:0051572]; negative regulation of histone H3-K9 methylation [GO:0051573]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of angiogenesis [GO:0045766]; positive regulation of DNA repair [GO:0045739]; positive regulation of gene expression [GO:0010628]; positive regulation of histone acetylation [GO:0035066]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of histone H3-K9 methylation [GO:0051574]; positive regulation of histone H4-K16 acetylation [GO:2000620]; positive regulation of histone H4-K20 methylation [GO:0070512]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA methylation [GO:0044030]; regulation of DNA repair [GO:0006282]; regulation of gene expression by genomic imprinting [GO:0006349]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estrogen [GO:0043627]; response to ionizing radiation [GO:0010212] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G778D	TCGA-39-5037	LUSC	TCGA	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.0556
p.E1548D	TCGA-44-8119	LUAD	TCGA	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation blocking phosphorylation signal	0.5
p.K175N	TCGA-50-6593	LUAD	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6918
p.K175N	TCGA-CV-A6K2	HNSC	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6918
p.K175N	DO52079	HNSC	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6918
p.K175N	DO24100	LUAD	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6918
p.T1569M	TCGA-55-6972	LUAD	TCGA	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation altering degron motif	0.7423
p.T1569M	TCGA-AJ-A3BH	UCEC	TCGA	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation altering degron motif	0.7423
p.T1569M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation altering degron motif	0.7423
p.T1569M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation altering degron motif	0.7423
p.S1487C	TCGA-92-8063	LUSC	TCGA	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.2778
p.D1603N	TCGA-AJ-A2QM	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.1944
p.E1602K	TCGA-AJ-A2QM	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.2222
p.E1602K	TCGA-XF-AAMX	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.2222
p.E597K	TCGA-B5-A1MR	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1389
p.T212A	TCGA-B5-A3FC	UCEC	TCGA	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation altering degron motif	0.7139
p.T212A	DO41871	UCEC	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation altering degron motif	0.7139
p.D1599H	TCGA-BH-A2L8	BRCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.3056
p.S184C	TCGA-CN-A6V1	HNSC	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6944
p.S184C	DO52048	HNSC	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6944
p.E1557K	TCGA-DR-A0ZM	CESC	TCGA	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation rewiring degron network	0.3056
p.R170L	TCGA-DU-6404	LGG	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1944
p.R170L	DO22207	LGG	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1944
p.R213S	TCGA-EE-A3AH	SKCM	TCGA	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.3056
p.R213S	DO37443	SKCM	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.3056
p.P209H	TCGA-ER-A19B	SKCM	TCGA	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation altering degron motif	0.7694
p.P209H	DO47491	SKCM	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation altering degron motif	0.7694
p.T1582A	TCGA-FI-A2D5	UCEC	TCGA	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.0833
p.S1494Y	TCGA-FU-A3TX	CESC	TCGA	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0833
p.G1492R	TCGA-FV-A23B	LIHC	TCGA	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1389
p.E765Q	TCGA-VS-A958	CESC	TCGA	VESSS	DEG_SPOP_SBC_1	764:768	Mutation altering degron motif	0.5633
p.E181D	TCGA-XQ-A8TA	PRAD	TCGA	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.5647
p.E181D	DO223662	PRAD	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.5647
p.V577M	DO51926	BLCA	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.0833
p.D597V	DO218669	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1389
p.Q579R	DO225328	BRCA	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1389
p.L1051I	DO1285	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation altering degron motif	0.7174
p.T176M	DO229355	BTCA	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6312
p.T590N	DO51628	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation altering degron motif	0.7055
p.S580F	DO44305	CESC	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1667
p.L767P	DO8690	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation altering degron motif	0.7582
p.D591N	DO222452	ESCA	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.3056
p.A760T	DO233163	GACA	ICGC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.2222
p.H769Y	DO14420	HNSC	ICGC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.3056
p.R595T	DO44431	HNSC	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1944
p.T195N	DO228948	LICA	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.0556
p.T167K	DO228971	LICA	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1111
p.T190N	DO229022	LICA	ICGC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.0833
p.V1046I	DO231663	LINC	ICGC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.3056
p.H1472R	DO23496	LINC	ICGC	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0833
p.H1472R	DO45053	LINC	ICGC	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0833
p.G200R	DO224566	LUSC	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.1944
p.G200R	DO231007	LUSC	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.1944
p.G211K	DO222843	MELA	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation altering degron motif	0.6442
p.S599G	DO51701	PAAD	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.0833
p.G1053R	DO36531	READ	ICGC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.2778
p.L222V	DO50291	SKCM	ICGC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation substituting flanking lysine	0.1667
p.P764S	DO223910	SKCM	ICGC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation altering degron motif	0.6752
p.C597W	DO41458	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1389
p.L1037F	DO41331	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation substituting flanking lysine	0.1667
p.S1054R	DO41379	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.25
p.D1567N	SIDM01057	Acute Myeloid Leukemia	GDSC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation rewiring degron network	0.2778
p.D1567N	SIDM01057	Acute Myeloid Leukemia	GDSC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.3056
p.D1567N	GDM-1	haematopoietic and lymphoid tissue	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation rewiring degron network	0.2778
p.D1567N	GDM-1	haematopoietic and lymphoid tissue	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.3056
p.V772A	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.2222
p.V772A	SIDM00414	Bladder Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.2222
p.V772A	Calu-3	lung	COSMIC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.2222
p.V772A	VM-CUB-1	urinary tract	COSMIC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.2222
p.S1563C	SIDM01139	Pancreatic Carcinoma	GDSC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation altering degron motif	0.7541
p.S1563C	PANC-02-03	pancreas	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation altering degron motif	0.7541
p.I1044V	SIDM00317	Kidney Carcinoma	GDSC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.25
p.I1044V	ACH-000171	Kidney Cancer	CCLE	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.25
p.I1044V	VMRC-RCZ	kidney	COSMIC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.25
p.S186Y	SIDM01039	Other Solid Cancers	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.S186Y	SIDM00793	Burkitt's Lymphoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.S186Y	SIDM00863	Burkitt's Lymphoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.S186Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.I1058V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.1389
p.I1058V	ACH-000823	Esophageal Cancer	CCLE	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.1389
p.I1058V	KYSE-140	oesophagus	COSMIC	VGSST	DEG_SPOP_SBC_1	1047:1051	Mutation rewiring degron network	0.1389
p.S1598P	SIDM00294	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation altering degron motif	0.6752
p.S1598P	SIDM00247	Gastric Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation altering degron motif	0.6752
p.S1598P	MKN45	stomach	COSMIC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation altering degron motif	0.6752
p.S1598P	LU-135	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation altering degron motif	0.6752
p.T1582I	SIDM00254	Neuroblastoma	GDSC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.0833
p.V1555M	SIDM00844	Burkitt's Lymphoma	GDSC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation rewiring degron network	0.25
p.S186F	SIDM00665	Gastric Carcinoma	GDSC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.S186F	ACH-000616	Gastric Cancer	CCLE	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.S186F	Hs746T	stomach	COSMIC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6389
p.S763F	SIDM00534	Colorectal Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.3056
p.S763F	ACH-000986	Colon/Colorectal Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.3056
p.S763F	HT-115	large intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.3056
p.P1600S	SIDM00150	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.2778
p.P1600S	KM12	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.2778
p.S1577P	ACH-000356	Gastric Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation blocking phosphorylation signal	0.6667
p.S1577P	ACH-000928	Endometrial/Uterine Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation blocking phosphorylation signal	0.6667
p.S1577P	ACH-001549	Lung Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation blocking phosphorylation signal	0.6667
p.S1577P	LU-135	lung	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation blocking phosphorylation signal	0.6667
p.S1577P	MKN45	stomach	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation blocking phosphorylation signal	0.6667
p.R1589C	ACH-000928	Endometrial/Uterine Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.1944
p.P1579S	ACH-000969	Colon/Colorectal Cancer	CCLE	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.1667
p.P1579S	KM12	large intestine	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.1667
p.A1599V	ACH-000981	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.3056
p.A1599V	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation rewiring degron network	0.3056
p.A1481V	ACH-000983	Leukemia	CCLE	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.5825
p.A1481V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.5825
p.T1548M	ACH-001127	Leukemia	CCLE	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation blocking phosphorylation signal	0.5
p.T1548M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation blocking phosphorylation signal	0.5
p.D1557N	ACH-001451	Cervical Cancer	CCLE	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation rewiring degron network	0.3056
p.S1495C	PANC-02-03	pancreas	COSMIC	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0556
p.N763T	LS-180	large intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	764:768	Mutation rewiring degron network	0.3056
p.Q1471H	RC-K8	haematopoietic and lymphoid tissue	COSMIC	ADSST	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0556
p.A1552V	DND-41	haematopoietic and lymphoid tissue	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation blocking phosphorylation signal	0.6111
p.R190Q	DMS-273	lung	COSMIC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.0833
p.C188F	NCI-H2347	lung	COSMIC	KTSVYIE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1389
p.E1582V	NCI-H2066	lung	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.0833
p.S1596A	NB14	autonomic ganglia	COSMIC	PSSTS	DEG_SPOP_SBC_1	1594:1598	Mutation altering degron motif	0.7588
p.M1581I	NB7	autonomic ganglia	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.1111
p.A1576V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ISLFSD	LIG_APCC_ABBA_1	1568:1573	Mutation rewiring degron network	0.25
p.R595Q	DMS-273	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.1944
p.C593F	NCI-H2347	lung	COSMIC	PISSS	DEG_SPOP_SBC_1	586:590	Mutation rewiring degron network	0.25
p.L199V	SF126	central nervous system	COSMIC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.1667
p.S1549A	NB14	autonomic ganglia	COSMIC	LEGTPYLE	DEG_SCF_FBW7_2	1558:1565	Mutation rewiring degron network	0.0833
p.K202R	HT-115	large intestine	COSMIC	LQITPQGT	DEG_SCF_FBW7_1	205:212	Mutation rewiring degron network	0.25

Kaplan plot for BRCA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRCA1

UniProt ID: P38398

Entrez ID: 672

Protein name: Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRCA1 in