DegronMD

Uniprot ID: P38398

Source protein: Breast cancer type 1 susceptibility protein

Source gene: BRCA1

Class: DEG_SPOP_SBC_1

Location: 1047:1051

E3 ligase: SPOP

DEGRON score: 0.9839

ASA_SCORE: 76.34

COIL: 0.9022

CONS_SCORE: 0.3633

DSS_SCORE: 0.5192

HELIX: 0.055

FCONS_SCORE: 1.0413

RIG_SCORE: 0.6413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1051I	DO1285	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	0.7174
p.V1046I	DO231663	LINC	ICGC	VGSST	DEG_SPOP_SBC_1	0.3056
p.G1053R	DO36531	READ	ICGC	VGSST	DEG_SPOP_SBC_1	0.2778
p.L1037F	DO41331	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.1667
p.S1054R	DO41379	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.25
p.I1044V	SIDM00317	Kidney Carcinoma	GDSC	VGSST	DEG_SPOP_SBC_1	0.25
p.I1044V	ACH-000171	Kidney Cancer	CCLE	VGSST	DEG_SPOP_SBC_1	0.25
p.I1044V	VMRC-RCZ	kidney	COSMIC	VGSST	DEG_SPOP_SBC_1	0.25
p.I1058V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VGSST	DEG_SPOP_SBC_1	0.1389
p.I1058V	ACH-000823	Esophageal Cancer	CCLE	VGSST	DEG_SPOP_SBC_1	0.1389
p.I1058V	KYSE-140	oesophagus	COSMIC	VGSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1047:1051	VGSST	SPOP	0.9839	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	489:493	VGSST	SPOP	0.7416	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	603:607	VGSST	SPOP	0.9489	More...
Q9BSJ2	Gamma-tubulin complex component 2	DEG_SPOP_SBC_1	113:117	VGSST	SPOP	0.7675	More...
Q9NZ56	Formin-2	DEG_SPOP_SBC_1	1249:1253	VGSST	SPOP	0.9636	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	414:418	VGSST	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons