DegronMD

Uniprot ID: Q02930

Source protein: Cyclic AMP-responsive element-binding protein 5

Source gene: CREB5

Class: DEG_SPOP_SBC_1

Location: 489:493

E3 ligase: SPOP

DEGRON score: 0.7416

ASA_SCORE: 70.06

COIL: 0.845

CONS_SCORE: 0.3173

DSS_SCORE: 0.4192

HELIX: 0.0852

FCONS_SCORE: 0.9675

RIG_SCORE: 0.6952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S495I	TCGA-AP-A059	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	0.2778
p.G490E	TCGA-FD-A43U	BLCA	TCGA	VGSST	DEG_SPOP_SBC_1	0.6087
p.S482F	TCGA-VQ-A8P2	STAD	TCGA	VGSST	DEG_SPOP_SBC_1	0.1389
p.G483E	DO645	BLCA	ICGC	VGSST	DEG_SPOP_SBC_1	0.1667
p.R494K	DO218173	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	0.3056
p.D496Y	DO25310	LUAD	ICGC	VGSST	DEG_SPOP_SBC_1	0.25
p.P499L	DO41488	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.1667
p.D496N	DO42713	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.25
p.S488I	DO41361	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.3056
p.V489I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VGSST	DEG_SPOP_SBC_1	0.7076
p.P499S	COLO-792	skin	COSMIC	VGSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1047:1051	VGSST	SPOP	0.9839	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	489:493	VGSST	SPOP	0.7416	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	603:607	VGSST	SPOP	0.9489	More...
Q9BSJ2	Gamma-tubulin complex component 2	DEG_SPOP_SBC_1	113:117	VGSST	SPOP	0.7675	More...
Q9NZ56	Formin-2	DEG_SPOP_SBC_1	1249:1253	VGSST	SPOP	0.9636	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	414:418	VGSST	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons