DegronMD

Uniprot ID: Q15032

Source protein: R3H domain-containing protein 1

Source gene: R3HDM1

Class: DEG_SPOP_SBC_1

Location: 414:418

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 71.12

COIL: 0.9142

CONS_SCORE: 0.4517

DSS_SCORE: 0.6217

HELIX: 0.0324

FCONS_SCORE: 1.0832

RIG_SCORE: 0.5368

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G419D	TCGA-2W-A8YY	CESC	TCGA	VGSST	DEG_SPOP_SBC_1	0.3056
p.L421V	TCGA-CR-6473	HNSC	TCGA	VGSST	DEG_SPOP_SBC_1	0.25
p.T418A	TCGA-FI-A2D5	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	0.7139
p.G405E	DO234319	ESAD	ICGC	VGSST	DEG_SPOP_SBC_1	0.1944
p.Q406H	DO49761	KIRP	ICGC	VGSST	DEG_SPOP_SBC_1	0.1111
p.V407F	DO228971	LICA	ICGC	VGSST	DEG_SPOP_SBC_1	0.1389
p.G427C	DO26468	LUSC	ICGC	VGSST	DEG_SPOP_SBC_1	0.0833
p.A421V	DO47717	STAD	ICGC	VGSST	DEG_SPOP_SBC_1	0.25
p.F414L	DO40884	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.6981
p.R427H	SNU-C5	large_intestine	COSMIC	VGSST	DEG_SPOP_SBC_1	0.0833
p.P418S	KYSE-150	oesophagus	COSMIC	VGSST	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1047:1051	VGSST	SPOP	0.9839	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	489:493	VGSST	SPOP	0.7416	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	603:607	VGSST	SPOP	0.9489	More...
Q9BSJ2	Gamma-tubulin complex component 2	DEG_SPOP_SBC_1	113:117	VGSST	SPOP	0.7675	More...
Q9NZ56	Formin-2	DEG_SPOP_SBC_1	1249:1253	VGSST	SPOP	0.9636	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	414:418	VGSST	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons