DegronMD

Uniprot ID: Q96EB6

Source protein: NAD-dependent protein deacetylase sirtuin-1

Source gene: SIRT1

Class: DEG_SPOP_SBC_1

Location: 603:607

E3 ligase: SPOP

DEGRON score: 0.9489

ASA_SCORE: 77.94

COIL: 0.8972

CONS_SCORE: 0.261

DSS_SCORE: 0.6658

HELIX: 0.0544

FCONS_SCORE: 0.9358

RIG_SCORE: 0.6164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A617V	TCGA-AA-3672	COAD	TCGA	VGSST	DEG_SPOP_SBC_1	0.0556
p.E609A	TCGA-XF-A9T0	BLCA	TCGA	VGSST	DEG_SPOP_SBC_1	0.2778

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00841	COREAD\|large_intestine	p.V383I (No)	GDSC	Selisistat	234.3646
SIDM00951	LAML\|acute_myeloid_leukaemia	p.L478V (No)	GDSC	Selisistat	77.29
SIDM00782	COREAD\|large_intestine	p.D379N (No)	GDSC	Selisistat	339.5601
SIDM01007	ALL\|lymphoblastic_leukemia	p.I256fs*2 (No)	GDSC	Selisistat	87.1222
SIDM00145	ALL\|lymphoblastic_leukemia	p.F414fs*13 (No)	GDSC	Selisistat	125.1844
SIDM00619	THCA\|thyroid	p.G355V (No)	GDSC	Selisistat	79.5472
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.G495D (No)	GDSC	Selisistat	367.6381
SIDM00304	OV\|ovary	p.S324fs*8 (No)	GDSC	Selisistat	447.8266
SIDM00602	STAD\|stomach	p.R237fs*11 (No)	GDSC	Selisistat	298.1516
SIDM00783	COREAD\|large_intestine	p.I256fs*2 (No)	GDSC	Selisistat	142.6314
SIDM00898	BRCA\|breast	p.T177I (No)	GDSC	Selisistat	287.6047
SIDM00685	GBM\|glioma	p.P393R (No)	GDSC	Selisistat	131.2062
SIDM00150	COREAD\|large_intestine	p.M407T (No)	GDSC	Selisistat	170.1144
SIDM00375	HNSC\|head_and_neck	p.A712T (No)	GDSC	Selisistat	325.9115
SIDM00789	COREAD\|large_intestine	p.R181W (No)	GDSC	Selisistat	198.5977
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.F414fs*13 (No)	GDSC	Selisistat	112.6936
SIDM00895	DLBC\|B_cell_lymphoma	p.S668F (No)	GDSC	Selisistat	124.056
SIDM01081	HNSC\|head_and_neck	p.I270K (No)	GDSC	Selisistat	292.294
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.A712T (No)	GDSC	Selisistat	332.9169
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.R649H (No)	GDSC	Selisistat	156.663
SIDM00193	COREAD\|large_intestine	p.K238T (No)	GDSC	Selisistat	474.4698
SIDM00193	COREAD\|large_intestine	p.E725G (No)	GDSC	Selisistat	474.4698
SIDM00118	COREAD\|large_intestine	p.E520* (No)	GDSC	Selisistat	256.5652
SIDM00118	COREAD\|large_intestine	p.E687K (No)	GDSC	Selisistat	256.5652

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1047:1051	VGSST	SPOP	0.9839	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	489:493	VGSST	SPOP	0.7416	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	603:607	VGSST	SPOP	0.9489	More...
Q9BSJ2	Gamma-tubulin complex component 2	DEG_SPOP_SBC_1	113:117	VGSST	SPOP	0.7675	More...
Q9NZ56	Formin-2	DEG_SPOP_SBC_1	1249:1253	VGSST	SPOP	0.9636	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	414:418	VGSST	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSST

Degron related mutations and impact score

Drug responses associated with SIRT1 mutations

All proteins holding degron of VGSST