DegronMD

Uniprot ID: Q9NZ56

Source protein: Formin-2

Source gene: FMN2

Class: DEG_SPOP_SBC_1

Location: 1249:1253

E3 ligase: SPOP

DEGRON score: 0.9636

ASA_SCORE: 73.46

COIL: 0.959

CONS_SCORE: 0.3749

DSS_SCORE: 0.505

HELIX: 0.0162

FCONS_SCORE: 0.9768

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1247S	TCGA-18-3409	LUSC	TCGA	VGSST	DEG_SPOP_SBC_1	0.2778
p.P1247S	DO26444	LUSC	ICGC	VGSST	DEG_SPOP_SBC_1	0.2778
p.V1259G	TCGA-43-A56V	LUSC	TCGA	VGSST	DEG_SPOP_SBC_1	0.1667
p.V1259G	DO45535	LUSC	ICGC	VGSST	DEG_SPOP_SBC_1	0.1667
p.P1257Q	TCGA-95-7039	LUAD	TCGA	VGSST	DEG_SPOP_SBC_1	0.2222
p.P1257Q	DO23907	LUAD	ICGC	VGSST	DEG_SPOP_SBC_1	0.2222
p.G1242C	TCGA-AG-3882	READ	TCGA	VGSST	DEG_SPOP_SBC_1	0.1389
p.G1242C	DO36724	READ	ICGC	VGSST	DEG_SPOP_SBC_1	0.1389
p.P1257S	TCGA-B5-A3FA	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	0.2222
p.P1257S	DO52402	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.2222
p.P1255R	TCGA-DD-AAVZ	LIHC	TCGA	VGSST	DEG_SPOP_SBC_1	0.2778
p.P1255R	DO52285	LIHC	ICGC	VGSST	DEG_SPOP_SBC_1	0.2778
p.P1239S	TCGA-EE-A3AH	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	0.0556
p.P1239S	DO222635	MELA	ICGC	VGSST	DEG_SPOP_SBC_1	0.0556
p.P1239S	DO37443	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	0.0556
p.P1247Q	TCGA-ER-A19C	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	0.2778
p.P1247Q	DO47353	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	0.2778
p.F1262L	TCGA-FR-A8YC	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	0.0833
p.F1262L	DO50301	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	0.0833
p.P1257T	TCGA-FS-A1Z0	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	0.2222
p.P1257T	DO37431	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	0.2222
p.G1261V	TCGA-HU-A4GU	STAD	TCGA	VGSST	DEG_SPOP_SBC_1	0.1111
p.G1261V	DO47849	STAD	ICGC	VGSST	DEG_SPOP_SBC_1	0.1111
p.S1251G	DO233241	GACA	ICGC	VGSST	DEG_SPOP_SBC_1	0.6993
p.S1252I	DO228948	LICA	ICGC	VGSST	DEG_SPOP_SBC_1	0.7341
p.T1256A	SIDM01059	Melanoma	GDSC	VGSST	DEG_SPOP_SBC_1	0.25
p.T1256A	ACH-000915	Skin Cancer	CCLE	VGSST	DEG_SPOP_SBC_1	0.25
p.T1256A	IPC-298	skin	COSMIC	VGSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1047:1051	VGSST	SPOP	0.9839	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	489:493	VGSST	SPOP	0.7416	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	603:607	VGSST	SPOP	0.9489	More...
Q9BSJ2	Gamma-tubulin complex component 2	DEG_SPOP_SBC_1	113:117	VGSST	SPOP	0.7675	More...
Q9NZ56	Formin-2	DEG_SPOP_SBC_1	1249:1253	VGSST	SPOP	0.9636	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	414:418	VGSST	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons