DegronMD

Uniprot ID: Q9BSJ2

Source protein: Gamma-tubulin complex component 2

Source gene: TUBGCP2

Class: DEG_SPOP_SBC_1

Location: 113:117

E3 ligase: SPOP

DEGRON score: 0.7675

ASA_SCORE: 80.92

COIL: 0.8994

CONS_SCORE: 0.2798

DSS_SCORE: 0.3211

HELIX: 0.087

FCONS_SCORE: 0.982

RIG_SCORE: 0.6566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A124G	TCGA-AJ-A3EK	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	0.1389
p.A124G	DO41584	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.1389
p.K103T	TCGA-AP-A059	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	0.5
p.K103T	DO41361	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	0.5
p.A110G	TCGA-S3-AA12	BRCA	TCGA	VGSST	DEG_SPOP_SBC_1	0.25
p.A110G	DO51224	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	0.25
p.S115N	TCGA-UF-A71A	HNSC	TCGA	VGSST	DEG_SPOP_SBC_1	0.7069
p.S115N	DO52106	HNSC	ICGC	VGSST	DEG_SPOP_SBC_1	0.7069
p.S119G	DO225005	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	0.2778
p.A112V	DO229248	THCA	ICGC	VGSST	DEG_SPOP_SBC_1	0.3056
p.R114L	NCI-H322M	lung	COSMIC	VGSST	DEG_SPOP_SBC_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1047:1051	VGSST	SPOP	0.9839	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	489:493	VGSST	SPOP	0.7416	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	603:607	VGSST	SPOP	0.9489	More...
Q9BSJ2	Gamma-tubulin complex component 2	DEG_SPOP_SBC_1	113:117	VGSST	SPOP	0.7675	More...
Q9NZ56	Formin-2	DEG_SPOP_SBC_1	1249:1253	VGSST	SPOP	0.9636	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	414:418	VGSST	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons