DegronMD - Q15032(R3HDM1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G419D	TCGA-2W-A8YY	CESC	TCGA	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.3056
p.R370Q	TCGA-3B-A9HT	SARC	TCGA	PWSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1389
p.L421V	TCGA-CR-6473	HNSC	TCGA	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.25
p.P802S	TCGA-EE-A3J5	SKCM	TCGA	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.6752
p.P802S	ACH-002396	Bone Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.6752
p.P802S	Sarc9371	bone	COSMIC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.6752
p.T418A	TCGA-FI-A2D5	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7139
p.Q814K	TCGA-S9-A7QX	LGG	TCGA	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1111
p.R807I	DO222574	BTCA	ICGC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.3056
p.G363D	DO223732	CESC	ICGC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7198
p.G363D	DO222755	COCA	ICGC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7198
p.G405E	DO234319	ESAD	ICGC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation substituting flanking lysine	0.1944
p.K810R	DO233884	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.2222
p.P794Q	DO44456	HNSC	ICGC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1111
p.L365V	DO14228	HNSC	ICGC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation blocking phosphorylation signal	0.7222
p.Q406H	DO49761	KIRP	ICGC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1111
p.H805D	DO49774	KIRP	ICGC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7688
p.N799K	DO44610	LGG	ICGC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.25
p.V407F	DO228971	LICA	ICGC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.S352F	DO23466	LINC	ICGC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1389
p.G427C	DO26468	LUSC	ICGC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.A421V	DO47717	STAD	ICGC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.25
p.F414L	DO40884	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6981
p.Y802D	DO43041	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7325
p.T362A	DO41331	UCEC	ICGC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7139
p.E351K	SIDM01318	Hepatocellular Carcinoma	GDSC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1111
p.K353N	ACH-000578	Lung Cancer	CCLE	PWSST	DEG_SPOP_SBC_1	359:363	Mutation substituting flanking lysine	0.2778
p.S354A	ACH-001610	Brain Cancer	CCLE	PWSST	DEG_SPOP_SBC_1	359:363	Mutation blocking phosphorylation signal	0.6389
p.S353G	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PWSST	DEG_SPOP_SBC_1	359:363	Mutation substituting flanking lysine	0.2778
p.Y811C	SNU-C5	large intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1944
p.G796R	BHY	upper aerodigestive tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.R427H	SNU-C5	large intestine	COSMIC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.P803S	Sarc9371	bone	COSMIC	PRTTS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.6752
p.P418S	KYSE-150	oesophagus	COSMIC	VGSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

R3HDM1

UniProt ID: Q15032

Entrez ID: 23518

Protein name: R3H domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for R3HDM1 in