DegronMD

Uniprot ID: Q15032

Source protein: R3H domain-containing protein 1

Source gene: R3HDM1

Class: DEG_SPOP_SBC_1

Location: 802:806

E3 ligase: SPOP

DEGRON score: 0.9836

ASA_SCORE: 86.66

COIL: 0.9492

CONS_SCORE: 0.3902

DSS_SCORE: 0.6729

HELIX: 0.0184

FCONS_SCORE: 0.9845

RIG_SCORE: 0.6562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P802S	TCGA-EE-A3J5	SKCM	TCGA	PRTTS	DEG_SPOP_SBC_1	0.6752
p.P802S	ACH-002396	Bone Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.6752
p.P802S	Sarc9371	bone	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6752
p.Q814K	TCGA-S9-A7QX	LGG	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1111
p.R807I	DO222574	BTCA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.K810R	DO233884	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2222
p.P794Q	DO44456	HNSC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1111
p.H805D	DO49774	KIRP	ICGC	PRTTS	DEG_SPOP_SBC_1	0.7688
p.N799K	DO44610	LGG	ICGC	PRTTS	DEG_SPOP_SBC_1	0.25
p.Y802D	DO43041	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.7325
p.Y811C	SNU-C5	large_intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.G796R	BHY	upper_aerodigestive_tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1667
p.P803S	Sarc9371	bone	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons