DegronMD

Uniprot ID: P49841

Source protein: Glycogen synthase kinase-3 beta

Source gene: GSK3B

Class: DEG_SPOP_SBC_1

Location: 5:9

E3 ligase: SPOP

DEGRON score: 0.9966

ASA_SCORE: 91.3

COIL: 0.81

CONS_SCORE: 0.3168

DSS_SCORE: 0.7558

HELIX: 0.1808

FCONS_SCORE: 1.0696

RIG_SCORE: 0.6672

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q19R	TCGA-V5-A7RE	ESCA	TCGA	PRTTS	DEG_SPOP_SBC_1	0.0556
p.A11S	DO48374	BLCA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2778

Drug responses associated with GSK3B mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.V126I (No)	GDSC	CHIR-99021	6.9608
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.V126I (No)	GDSC	KIN001-042	53.7157
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.V126I (No)	GDSC	SB216763	37.8172
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.V126I (No)	GDSC	CHIR-99021	9.3615
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.V126I (No)	GDSC	AZD7969	2.2189
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.A410V (No)	GDSC	CHIR-99021	33.0317
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.A410V (No)	GDSC	KIN001-042	28.5945
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.A410V (No)	GDSC	SB216763	24.5158
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.A410V (No)	GDSC	CHIR-99021	16.7707
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.A410V (No)	GDSC	AZD7969	4.9304
SIDM01086	ALL\|leukemia	p.R367* (No)	GDSC	CHIR-99021	2.0173
SIDM01086	ALL\|leukemia	p.R367* (No)	GDSC	KIN001-042	80.334
SIDM01086	ALL\|leukemia	p.R367* (No)	GDSC	SB216763	6.14
SIDM01086	ALL\|leukemia	p.R367* (No)	GDSC	CHIR-99021	13.5883
SIDM01086	ALL\|leukemia	p.R367* (No)	GDSC	AZD7969	2.5926
SIDM01086	ALL\|leukemia	p.F318L (No)	GDSC	CHIR-99021	2.0173
SIDM01086	ALL\|leukemia	p.F318L (No)	GDSC	KIN001-042	80.334
SIDM01086	ALL\|leukemia	p.F318L (No)	GDSC	SB216763	6.14
SIDM01086	ALL\|leukemia	p.F318L (No)	GDSC	CHIR-99021	13.5883
SIDM01086	ALL\|leukemia	p.F318L (No)	GDSC	AZD7969	2.5926
SIDM00680	COREAD\|large_intestine	p.D33G (No)	GDSC	CHIR-99021	41.3706
SIDM00680	COREAD\|large_intestine	p.D33G (No)	GDSC	KIN001-042	105.6363
SIDM00680	COREAD\|large_intestine	p.D33G (No)	GDSC	SB216763	96.7306
SIDM00680	COREAD\|large_intestine	p.D33G (No)	GDSC	CHIR-99021	237.7577
SIDM00680	COREAD\|large_intestine	p.D33G (No)	GDSC	AZD7969	15.5816
SIDM00680	COREAD\|large_intestine	p.D33G (No)	GDSC	SB216763	224.79
SIDM00121	ALL\|lymphoblastic_leukemia	p.R96* (No)	GDSC	CHIR-99021	6.6744
SIDM00121	ALL\|lymphoblastic_leukemia	p.R96* (No)	GDSC	KIN001-042	82.8107
SIDM00121	ALL\|lymphoblastic_leukemia	p.R96* (No)	GDSC	SB216763	39.2571
SIDM00121	ALL\|lymphoblastic_leukemia	p.R96* (No)	GDSC	CHIR-99021	28.7855
SIDM00121	ALL\|lymphoblastic_leukemia	p.R96* (No)	GDSC	AZD7969	3.685
SIDM00527	COREAD\|large_intestine	p.R319Q (No)	GDSC	CHIR-99021	28.5631
SIDM00527	COREAD\|large_intestine	p.R319Q (No)	GDSC	KIN001-042	95.229
SIDM00527	COREAD\|large_intestine	p.R319Q (No)	GDSC	SB216763	102.2451
SIDM00527	COREAD\|large_intestine	p.R319Q (No)	GDSC	CHIR-99021	29.6209
SIDM00527	COREAD\|large_intestine	p.R319Q (No)	GDSC	AZD7969	3.0592
SIDM00527	COREAD\|large_intestine	p.R319Q (No)	GDSC	SB216763	79.41
SIDM01210	LGG\|glioma	p.R332H (No)	GDSC	CHIR-99021	50.329
SIDM01210	LGG\|glioma	p.R332H (No)	GDSC	KIN001-042	259.0655
SIDM01210	LGG\|glioma	p.R332H (No)	GDSC	SB216763	239.205
SIDM01210	LGG\|glioma	p.R332H (No)	GDSC	CHIR-99021	174.7433
SIDM01210	LGG\|glioma	p.R332H (No)	GDSC	AZD7969	33.4413
SIDM00568	STAD\|stomach	p.T8P (Yes)	GDSC	CHIR-99021	45.8182
SIDM00568	STAD\|stomach	p.T8P (Yes)	GDSC	KIN001-042	103.228
SIDM00568	STAD\|stomach	p.T8P (Yes)	GDSC	AZD7969	12.9374
SIDM00530	ESCA\|oesophagus	p.R332H (No)	GDSC	KIN001-042	75.2983
SIDM00530	ESCA\|oesophagus	p.R332H (No)	GDSC	SB216763	126.6498
SIDM00530	ESCA\|oesophagus	p.R332H (No)	GDSC	CHIR-99021	37.4656
SIDM00530	ESCA\|oesophagus	p.R332H (No)	GDSC	AZD7969	16.2457
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.H310Q (No)	GDSC	CHIR-99021	0.7229
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.H310Q (No)	GDSC	KIN001-042	91.8155
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.H310Q (No)	GDSC	SB216763	95.5116
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.H310Q (No)	GDSC	CHIR-99021	43.7491
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.H310Q (No)	GDSC	AZD7969	3.2333
SIDM00489	HNSC\|head_and_neck	p.L75V (No)	GDSC	CHIR-99021	4.1762
SIDM00489	HNSC\|head_and_neck	p.L75V (No)	GDSC	KIN001-042	95.3155
SIDM00489	HNSC\|head_and_neck	p.L75V (No)	GDSC	SB216763	33.2896
SIDM00489	HNSC\|head_and_neck	p.L75V (No)	GDSC	CHIR-99021	31.9381
SIDM00489	HNSC\|head_and_neck	p.L75V (No)	GDSC	AZD7969	7.2255
SIDM00180	KIRC\|kidney	p.T8P (Yes)	GDSC	CHIR-99021	5.2743
SIDM00180	KIRC\|kidney	p.T8P (Yes)	GDSC	KIN001-042	103.5315
SIDM00180	KIRC\|kidney	p.T8P (Yes)	GDSC	CHIR-99021	3.3603
SIDM00180	KIRC\|kidney	p.T8P (Yes)	GDSC	AZD7969	1.6199
SIDM01096	COREAD\|large_intestine	p.P392S (No)	GDSC	CHIR-99021	9.7783
SIDM01096	COREAD\|large_intestine	p.P392S (No)	GDSC	KIN001-042	102.51
SIDM01096	COREAD\|large_intestine	p.P392S (No)	GDSC	SB216763	87.0511
SIDM01096	COREAD\|large_intestine	p.P392S (No)	GDSC	CHIR-99021	27.4227
SIDM01096	COREAD\|large_intestine	p.P392S (No)	GDSC	AZD7969	2.0503
SIDM01096	COREAD\|large_intestine	p.P392S (No)	GDSC	SB216763	45.332
SIDM00150	COREAD\|large_intestine	p.G65E (No)	GDSC	CHIR-99021	12.5898
SIDM00150	COREAD\|large_intestine	p.G65E (No)	GDSC	KIN001-042	34.0713
SIDM00150	COREAD\|large_intestine	p.G65E (No)	GDSC	SB216763	66.8307
SIDM00150	COREAD\|large_intestine	p.G65E (No)	GDSC	CHIR-99021	69.7656
SIDM00150	COREAD\|large_intestine	p.G65E (No)	GDSC	AZD7969	89.2348
SIDM00150	COREAD\|large_intestine	p.G65E (No)	GDSC	SB216763	325.75
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.Q164* (No)	GDSC	CHIR-99021	9.6669
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.Q164* (No)	GDSC	KIN001-042	350.5825
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.Q164* (No)	GDSC	SB216763	24.1334
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.Q164* (No)	GDSC	CHIR-99021	36.402
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.Q164* (No)	GDSC	AZD7969	15.1133
SIDM01146	STAD\|stomach	p.R319* (No)	GDSC	CHIR-99021	56.5459
SIDM01146	STAD\|stomach	p.R319* (No)	GDSC	KIN001-042	220.3096
SIDM01146	STAD\|stomach	p.R319* (No)	GDSC	SB216763	40.4403
SIDM01146	STAD\|stomach	p.R319* (No)	GDSC	CHIR-99021	81.2308
SIDM01146	STAD\|stomach	p.R319* (No)	GDSC	AZD7969	52.2525
SIDM00562	BRCA\|breast	p.S21L (No)	GDSC	CHIR-99021	33.1728
SIDM00562	BRCA\|breast	p.S21L (No)	GDSC	KIN001-042	52.523
SIDM00562	BRCA\|breast	p.S21L (No)	GDSC	SB216763	90.3008
SIDM00562	BRCA\|breast	p.S21L (No)	GDSC	CHIR-99021	122.4451
SIDM00562	BRCA\|breast	p.S21L (No)	GDSC	AZD7969	15.7659
SIDM00562	BRCA\|breast	p.S21L (No)	GDSC	SB216763	150.8
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.T8P (Yes)	GDSC	CHIR-99021	23.2306
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.T8P (Yes)	GDSC	KIN001-042	58.4963
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.T8P (Yes)	GDSC	SB216763	28.1925
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.T8P (Yes)	GDSC	CHIR-99021	196.7024
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.T8P (Yes)	GDSC	AZD7969	4.3351
SIDM00193	COREAD\|large_intestine	p.T403A (No)	GDSC	KIN001-042	221.4046
SIDM00193	COREAD\|large_intestine	p.T403A (No)	GDSC	CHIR-99021	142.3183
SIDM00193	COREAD\|large_intestine	p.T403A (No)	GDSC	AZD7969	13.0599
SIDM00193	COREAD\|large_intestine	p.T403A (No)	GDSC	SB216763	157.4

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTTS

Degron related mutations and impact score

Drug responses associated with GSK3B mutations

All proteins holding degron of PRTTS