DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: DEG_SPOP_SBC_1

Location: 618:622

E3 ligase: SPOP

DEGRON score: 0.9725

ASA_SCORE: 99.92

COIL: 0.9232

CONS_SCORE: 0.4549

DSS_SCORE: 0.6623

HELIX: 0.026

FCONS_SCORE: 0.9168

RIG_SCORE: 0.6777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R615Q	TCGA-AD-6888	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.25
p.R615Q	DO10435	COAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.25
p.T616I	TCGA-B5-A3FC	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.2778
p.T616I	DO41871	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2778
p.R615W	TCGA-EO-A22U	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.25
p.R615W	DO43755	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.25
p.A626V	TCGA-VQ-A8P2	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.2222
p.A626V	DO234446	ESAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2222
p.A626V	DO233106	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2222
p.A626V	DO51761	STAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2222
p.Q610H	DO50438	ESAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2222
p.A626T	DO27813	MALY	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2222
p.A620T	DO220879	MELA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.7139
p.V629M	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.V629M	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.T613K	SIDM00120	Prostate Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.T613K	DU-145	prostate	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P618S	NCI-H1417	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6752
p.T612K	DU-145	prostate	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6111
p.V628M	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1667
p.P617S	NCI-H1417	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.D618N	639-V	urinary_tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons