DegronMD - P50281(MMP14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F289S	TCGA-AX-A1CE	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.F289S	DO42280	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.P290L	TCGA-HU-A4GX	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.P290L	DO47757	STAD	ICGC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.L18F	TCGA-IB-7651	PAAD	TCGA	AQSSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0556
p.L18F	DO46657	PAAD	ICGC	AQSSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0556
p.R302W	DO233259	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056
p.G26C	DO228976	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2778
p.A23S	DO228971	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.A21S	DO229041	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.P309L	SIDM00216	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.P309L	ACH-000989	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.P309L	SNU-175	large intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.P297S	SIDM00150	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6752
p.P297S	ACH-000969	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6752
p.P297S	KM12	large intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6752
p.T299S	SIDM01033	Bladder Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6005
p.T299S	ACH-000486	Bladder Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6005
p.T299S	KU-19-19	urinary tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6005

Kaplan plot for MMP14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMP14

UniProt ID: P50281

Entrez ID: 4323

Protein name: Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMP14 in