DegronMD

Uniprot ID: P50281

Source protein: Matrix metalloproteinase-14

Source gene: MMP14

Class: DEG_SPOP_SBC_1

Location: 28:32

E3 ligase: SPOP

DEGRON score: 0.7543

ASA_SCORE: 82.12

COIL: 0.8204

CONS_SCORE: 0.2743

DSS_SCORE: 0.2685

HELIX: 0.14

FCONS_SCORE: 0.8609

RIG_SCORE: 0.6513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L18F	TCGA-IB-7651	PAAD	TCGA	AQSSS	DEG_SPOP_SBC_1	0.0556
p.L18F	DO46657	PAAD	ICGC	AQSSS	DEG_SPOP_SBC_1	0.0556
p.G26C	DO228976	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.2778
p.A23S	DO228971	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1944
p.A21S	DO229041	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24394	Interleukin-4 receptor subunit alpha	DEG_SPOP_SBC_1	802:806	AQSSS	SPOP	0.9859	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	28:32	AQSSS	SPOP	0.7543	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	372:376	AQSSS	SPOP	0.9419	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2384:2388	AQSSS	SPOP	0.8066	More...
Q13616	Cullin-1	DEG_SPOP_SBC_1	412:416	AQSSS	SPOP	0.5305	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	381:385	AQSSS	SPOP	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons