DegronMD

Uniprot ID: P24394

Source protein: Interleukin-4 receptor subunit alpha

Source gene: IL4R

Class: DEG_SPOP_SBC_1

Location: 802:806

E3 ligase: SPOP

DEGRON score: 0.9859

ASA_SCORE: 77.82

COIL: 0.886

CONS_SCORE: 0.4265

DSS_SCORE: 0.5565

HELIX: 0.0614

FCONS_SCORE: 1.2397

RIG_SCORE: 0.5682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P809L	TCGA-AB-2806	LAML	TCGA	AQSSS	DEG_SPOP_SBC_1	0.25
p.P809L	DO21283	LAML	ICGC	AQSSS	DEG_SPOP_SBC_1	0.25
p.V815F	TCGA-BP-5191	KIRC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.0833
p.V815F	DO19148	KIRC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.0833
p.K810R	TCGA-FD-A6TC	BLCA	TCGA	AQSSS	DEG_SPOP_SBC_1	0.3333
p.K810R	DO49755	BLCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.3333
p.V812M	DO36083	PBCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1667
p.S793P	SIDM00980	Gastric Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.0833
p.S793P	ACH-000948	Gastric Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	0.0833
p.S793P	23132-87	stomach	COSMIC	AQSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24394	Interleukin-4 receptor subunit alpha	DEG_SPOP_SBC_1	802:806	AQSSS	SPOP	0.9859	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	28:32	AQSSS	SPOP	0.7543	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	372:376	AQSSS	SPOP	0.9419	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2384:2388	AQSSS	SPOP	0.8066	More...
Q13616	Cullin-1	DEG_SPOP_SBC_1	412:416	AQSSS	SPOP	0.5305	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	381:385	AQSSS	SPOP	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons