DegronMD - Q02446(SP4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N780S	TCGA-12-0688	GBM	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.2778
p.N780S	DO11088	GBM	ICGC	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.2778
p.T779N	TCGA-18-3416	LUSC	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.3056
p.T779N	DO26423	LUSC	ICGC	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.3056
p.T330R	TCGA-29-1698	OV	TCGA	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.T330R	DO28531	OV	ICGC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.S187L	TCGA-4Z-AA84	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7667
p.S187L	DO218988	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7667
p.G133R	TCGA-56-1622	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.G133R	DO26461	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.Q195E	TCGA-60-2714	LUSC	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1111
p.Q195E	DO26530	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1111
p.A106V	TCGA-A3-3357	KIRC	TCGA	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5825
p.A106V	TCGA-DJ-A1QI	THCA	TCGA	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5825
p.A106V	DO20396	KIRC	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5825
p.A106V	DO40063	THCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5825
p.S770L	TCGA-AA-A010	COAD	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	TCGA-AX-A06F	UCEC	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	TCGA-B5-A11N	UCEC	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	TCGA-EO-A22U	UCEC	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	DO41752	UCEC	ICGC	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	DO43755	UCEC	ICGC	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	DO41458	UCEC	ICGC	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.S770L	ACH-001991	Primary	CCLE	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation blocking phosphorylation signal	0.7222
p.G176R	TCGA-BJ-A28S	THCA	TCGA	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.G176R	DO48141	THCA	ICGC	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.S112L	TCGA-CN-6995	HNSC	TCGA	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation altering degron motif	0.6556
p.S112L	TCGA-CN-6995	HNSC	TCGA	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.7667
p.S112L	DO14854	HNSC	ICGC	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation altering degron motif	0.6556
p.S112L	DO14854	HNSC	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.7667
p.S124L	TCGA-D1-A103	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.8778
p.S124L	TCGA-GF-A6C9	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.8778
p.S124L	DO51254	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.8778
p.S124L	DO42312	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.8778
p.E782K	TCGA-E7-A6ME	BLCA	TCGA	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.2222
p.E782K	DO51874	BLCA	ICGC	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.2222
p.P365A	TCGA-EJ-5507	PRAD	TCGA	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365A	DO36257	PRAD	ICGC	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.S320F	TCGA-IW-A3M6	SARC	TCGA	PSSST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7982
p.S320F	DO220178	SARC	ICGC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7982
p.S320F	SIDM00280	Gastric Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7982
p.S320F	ACH-000560	Gastric Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7982
p.S320F	ECC10	stomach	COSMIC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7982
p.S310F	TCGA-MV-A51V	BLCA	TCGA	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.S310F	DO474	BLCA	ICGC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.S122C	TCGA-XF-A8HE	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7541
p.S122C	DO49797	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7541
p.Q119E	DO225215	BRCA	ICGC	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation rewiring degron network	0.25
p.Q119E	DO225215	BRCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.1389
p.Q119E	DO225215	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.Q119E	DO227836	BRCA	ICGC	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation rewiring degron network	0.25
p.Q119E	DO227836	BRCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.1389
p.Q119E	DO227836	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.S123I	DO229027	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7341
p.A111S	DO229041	LICA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.6477
p.A372G	DO50934	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.754
p.A372T	DO23440	LINC	ICGC	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7139
p.L104I	DO27931	ORCA	ICGC	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation rewiring degron network	0.1111
p.L104I	DO27931	ORCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation rewiring degron network	0.3056
p.N385D	SIDM01314	Colorectal Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0833
p.M383I	SIDM02021	Esophageal Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P110S	SIDM00321	Ovarian Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM00607	Glioblastoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM00609	Kidney Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM01617	Endometrial Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM01570	Ovarian Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM01498	Acute Myeloid Leukemia	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.P110S	SIDM01460	Glioma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	105:112	Mutation altering degron motif	0.5641
p.S362P	SIDM00845	Burkitt's Lymphoma	GDSC	AQSSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0556
p.T330M	SIDM01197	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.T330M	ACH-000722	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.T330M	ACH-001373	Ovarian Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.T330M	SNU-C1	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.P315S	SIDM00217	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.P315S	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.P315S	SNU-1040	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.Q197K	ACH-000961	Endometrial/Uterine Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0556
p.K113Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation altering degron motif	0.6944
p.S126N	ACH-001484	Leukemia	CCLE	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation blocking phosphorylation signal	0.5
p.S126N	ACH-001484	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	120:124	Mutation blocking phosphorylation signal	0.7222
p.S126N	ACH-001485	Leukemia	CCLE	SKENN	DEG_APCC_KENBOX_2	112:116	Mutation blocking phosphorylation signal	0.5
p.S126N	ACH-001485	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	120:124	Mutation blocking phosphorylation signal	0.7222
p.S123G	ACH-001556	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6993
p.Q768E	ACH-001652	Endometrial/Uterine Cancer	CCLE	PATPNVS	DEG_SCF_FBW7_1	772:778	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP4

UniProt ID: Q02446

Entrez ID: 6671

Protein name: Transcription factor Sp4 (SPR-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP4 in