DegronMD

Uniprot ID: Q02446

Source protein: Transcription factor Sp4

Source gene: SP4

Class: DEG_SCF_FBW7_1

Location: 105:112

E3 ligase: FBXW7

DEGRON score: 0.7512

ASA_SCORE: 62.875

COIL: 0.713

CONS_SCORE: 0.3137

DSS_SCORE: 0.528

HELIX: 0.0568

FCONS_SCORE: 1.0234

RIG_SCORE: 0.6946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A106V	TCGA-A3-3357	KIRC	TCGA	VASTPPAS	DEG_SCF_FBW7_1	0.5825
p.A106V	TCGA-DJ-A1QI	THCA	TCGA	VASTPPAS	DEG_SCF_FBW7_1	0.5825
p.A106V	DO20396	KIRC	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.5825
p.A106V	DO40063	THCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.5825
p.S112L	TCGA-CN-6995	HNSC	TCGA	VASTPPAS	DEG_SCF_FBW7_1	0.7667
p.S112L	DO14854	HNSC	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.7667
p.Q119E	DO225215	BRCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.1389
p.Q119E	DO227836	BRCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.1389
p.A111S	DO229041	LICA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.6477
p.L104I	DO27931	ORCA	ICGC	VASTPPAS	DEG_SCF_FBW7_1	0.3056
p.P110S	SIDM00321	Ovarian Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM00607	Glioblastoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM00609	Kidney Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM01617	Endometrial Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM01570	Ovarian Carcinoma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM01498	Acute Myeloid Leukemia	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641
p.P110S	SIDM01460	Glioma	GDSC	VASTPPAS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02446	Transcription factor Sp4	DEG_SCF_FBW7_1	105:112	VASTPPAS	FBXW7	0.7512	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons