DegronMD

Uniprot ID: Q02446

Source protein: Transcription factor Sp4

Source gene: SP4

Class: DEG_APCC_KENBOX_2

Location: 112:116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8709

ASA_SCORE: 100.28

COIL: 0.7138

CONS_SCORE: 0.2872

DSS_SCORE: 0.6173

HELIX: 0.1572

FCONS_SCORE: 0.8841

RIG_SCORE: 0.6113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S112L	TCGA-CN-6995	HNSC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.6556
p.S112L	DO14854	HNSC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.6556
p.Q119E	DO225215	BRCA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.25
p.Q119E	DO227836	BRCA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.25
p.L104I	DO27931	ORCA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.K113Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	0.6944
p.S126N	ACH-001484	Leukemia	CCLE	SKENN	DEG_APCC_KENBOX_2	0.5
p.S126N	ACH-001485	Leukemia	CCLE	SKENN	DEG_APCC_KENBOX_2	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29508	Serpin B3	DEG_APCC_KENBOX_2	22:26	SKENN	APC,CDC20,FZR1	0.5575	More...
Q02446	Transcription factor Sp4	DEG_APCC_KENBOX_2	112:116	SKENN	APC,CDC20,FZR1	0.8709	More...
Q86W56	Poly	DEG_APCC_KENBOX_2	98:102	SKENN	APC,CDC20,FZR1	0.9861	More...
Q9BXS6	Nucleolar and spindle-associated protein 1	DEG_APCC_KENBOX_2	383:387	SKENN	APC,CDC20,FZR1	0.7978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons