DegronMD - Q9BXS6(NUSAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K374T	TCGA-85-6561	LUSC	TCGA	SKENN	DEG_APCC_KENBOX_2	383:387	Mutation substituting flanking lysine	0.1944
p.K374T	DO26518	LUSC	ICGC	SKENN	DEG_APCC_KENBOX_2	383:387	Mutation substituting flanking lysine	0.1944
p.L164I	TCGA-AJ-A5DW	UCEC	TCGA	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation altering degron motif	0.6063
p.L164I	DO50075	UCEC	ICGC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation altering degron motif	0.6063
p.Q391H	TCGA-B5-A0JN	UCEC	TCGA	SKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.2222
p.Q391H	DO41943	UCEC	ICGC	SKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.2222
p.D167Y	TCGA-G2-A2EO	BLCA	TCGA	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation altering degron motif	0.7325
p.D166Y	DO456	BLCA	ICGC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation altering degron motif	0.7325
p.R152T	DO222744	ESCA	ICGC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation rewiring degron network	0.0833
p.V393F	DO229032	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.1667
p.K161R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation altering degron motif	0.6126
p.K161R	NCI-H2342	lung	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation altering degron motif	0.6126
p.H373Y	SIDM00217	Colorectal Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	383:387	Mutation rewiring degron network	0.0556
p.K155R	SIDM01377	Ovarian Carcinoma	GDSC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation substituting flanking lysine	0.2778
p.H169Y	ACH-000680	Colon/Colorectal Cancer	CCLE	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation blocking phosphorylation signal	0.7222
p.H169Y	SW948	large intestine	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation blocking phosphorylation signal	0.7222
p.G173E	GR-ST	haematopoietic and lymphoid tissue	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation rewiring degron network	0.1667
p.H177Y	SW948	large intestine	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation rewiring degron network	0.0556
p.K160R	NCI-H2342	lung	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation rewiring degron network	0.3056
p.G172E	GR-ST	haematopoietic and lymphoid tissue	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation rewiring degron network	0.1944
p.G158E	GR-ST	haematopoietic and lymphoid tissue	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	161:167	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for NUSAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUSAP1

UniProt ID: Q9BXS6

Entrez ID: 51203

Protein name: Nucleolar and spindle-associated protein 1 (NuSAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUSAP1 in