DegronMD

Uniprot ID: Q9BXS6

Source protein: Nucleolar and spindle-associated protein 1

Source gene: NUSAP1

Class: DEG_APCC_KENBOX_2

Location: 383:387

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7978

ASA_SCORE: 98.68

COIL: 0.7356

CONS_SCORE: 0.513

DSS_SCORE: 0.5253

HELIX: 0.2206

FCONS_SCORE: 0.9424

RIG_SCORE: 0.6992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K374T	TCGA-85-6561	LUSC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.1944
p.K374T	DO26518	LUSC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1944
p.Q391H	TCGA-B5-A0JN	UCEC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.2222
p.Q391H	DO41943	UCEC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.2222
p.V393F	DO229032	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1667
p.H373Y	SIDM00217	Colorectal Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29508	Serpin B3	DEG_APCC_KENBOX_2	22:26	SKENN	APC,CDC20,FZR1	0.5575	More...
Q02446	Transcription factor Sp4	DEG_APCC_KENBOX_2	112:116	SKENN	APC,CDC20,FZR1	0.8709	More...
Q86W56	Poly	DEG_APCC_KENBOX_2	98:102	SKENN	APC,CDC20,FZR1	0.9861	More...
Q9BXS6	Nucleolar and spindle-associated protein 1	DEG_APCC_KENBOX_2	383:387	SKENN	APC,CDC20,FZR1	0.7978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons