DegronMD - P29508(SERPINB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F28L	TCGA-06-5416	GBM	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.F28L	DO10880	GBM	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.N48K	TCGA-50-5930	LUAD	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1667
p.N48K	DO25189	LUAD	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1667
p.G44V	TCGA-53-7626	LUAD	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.G44V	DO23774	LUAD	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.P31L	TCGA-55-6970	LUAD	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1944
p.P31L	DO24421	LUAD	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1944
p.D14N	TCGA-AX-A1C9	UCEC	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.D14N	DO43098	UCEC	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.G68E	TCGA-AX-A3FS	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	DO220899	MELA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	DO40879	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	SIDM00437	Acute Myeloid Leukemia	GDSC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	SIDM00523	Small Cell Lung Carcinoma	GDSC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	ACH-000362	Leukemia	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	ACH-000698	Lung Cancer	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	ACH-001574	Leukemia	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	DMS-53	lung	COSMIC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.G68E	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1111
p.D14H	TCGA-BA-4077	HNSC	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.D14H	DO15647	HNSC	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.D14H	SIDM01133	Other Solid Cancers	GDSC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.L57P	TCGA-BS-A0UF	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.7582
p.L57P	DO41488	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.7582
p.L57I	TCGA-E6-A1LX	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.6063
p.L57I	DO41020	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.6063
p.G44A	TCGA-EE-A20C	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.G44A	DO47665	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.G44R	TCGA-EE-A20C	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.G44R	DO47665	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.L57F	TCGA-EO-A22R	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.6981
p.L57F	DO229479	SKCA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.6981
p.L57F	DO42713	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation altering degron motif	0.6981
p.E64K	TCGA-ER-A19E	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.2222
p.E64K	DO47542	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.2222
p.R20S	TCGA-EY-A1GD	UCEC	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.R20S	DO42129	UCEC	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.R20S	SIDM00767	Small Cell Lung Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.R20S	ACH-001136	Lung Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.R20S	NCI-H187	lung	COSMIC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.S22L	TCGA-GN-A8LK	SKCM	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.6556
p.S22L	DO51259	SKCM	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.6556
p.L15M	TCGA-KC-A4BR	PRAD	TCGA	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1389
p.L15M	DO228548	PRAD	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1389
p.L15M	DO219279	PRAD	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1389
p.A70T	TCGA-W3-AA1R	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.A70T	DO51275	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556
p.T49A	DO227906	COCA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1944
p.N65K	DO228985	LICA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1944
p.N65K	DO229031	LICA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1944
p.N65K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1944
p.N65K	ACH-000912	Lung Cancer	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.1944
p.T35K	DO228986	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation blocking phosphorylation signal	0.5278
p.F13L	DO229028	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0833
p.S33R	DO229034	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1389
p.N25K	DO229038	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.6918
p.P31T	DO231758	LINC	ICGC	SKENN	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1944
p.G44T	DO222775	MELA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	54:60	Mutation rewiring degron network	0.0556

Kaplan plot for SERPINB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERPINB3

UniProt ID: P29508

Entrez ID: 6317

Protein name: Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERPINB3 in