DegronMD

Uniprot ID: P29508

Source protein: Serpin B3

Source gene: SERPINB3

Class: LIG_APCC_ABBAyCdc20_2

Location: 54:60

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8963

ASA_SCORE: 68.0429

COIL: 0.5983

CONS_SCORE: 0.4693

DSS_SCORE: 0.3285

HELIX: 0.3883

FCONS_SCORE: 1.2481

RIG_SCORE: 0.8753

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N48K	TCGA-50-5930	LUAD	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N48K	DO25189	LUAD	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G44V	TCGA-53-7626	LUAD	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G44V	DO23774	LUAD	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G68E	TCGA-AX-A3FS	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	DO220899	MELA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	DO40879	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	SIDM00437	Acute Myeloid Leukemia	GDSC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	SIDM00523	Small Cell Lung Carcinoma	GDSC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	ACH-000362	Leukemia	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	ACH-000698	Lung Cancer	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	ACH-001574	Leukemia	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	DMS-53	lung	COSMIC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G68E	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L57P	TCGA-BS-A0UF	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.7582
p.L57P	DO41488	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.7582
p.L57I	TCGA-E6-A1LX	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.6063
p.L57I	DO41020	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.6063
p.G44A	TCGA-EE-A20C	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G44A	DO47665	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G44R	TCGA-EE-A20C	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G44R	DO47665	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.L57F	TCGA-EO-A22R	UCEC	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.6981
p.L57F	DO229479	SKCA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.6981
p.L57F	DO42713	UCEC	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.6981
p.E64K	TCGA-ER-A19E	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E64K	DO47542	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A70T	TCGA-W3-AA1R	SKCM	TCGA	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A70T	DO51275	SKCM	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T49A	DO227906	COCA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N65K	DO228985	LICA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N65K	DO229031	LICA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N65K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N65K	ACH-000912	Lung Cancer	CCLE	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G44T	DO222775	MELA	ICGC	KKVLHFD	LIG_APCC_ABBAyCdc20_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKVLHFD

Degron related mutations and impact score

Drug responses associated with SERPINB3 mutations

All proteins holding degron of KKVLHFD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29508	Serpin B3	LIG_APCC_ABBAyCdc20_2	54:60	KKVLHFD	APC,CDC20,FZR1	0.8963	More...