DegronMD

Uniprot ID: P29508

Source protein: Serpin B3

Source gene: SERPINB3

Class: DEG_APCC_KENBOX_2

Location: 22:26

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5575

ASA_SCORE: 81.92

COIL: 0.906

CONS_SCORE: 0.3476

DSS_SCORE: 0.1106

HELIX: 0.0438

FCONS_SCORE: 0.6293

RIG_SCORE: 0.7896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F28L	TCGA-06-5416	GBM	TCGA	SKENN	DEG_APCC_KENBOX_2	0.2778
p.F28L	DO10880	GBM	ICGC	SKENN	DEG_APCC_KENBOX_2	0.2778
p.P31L	TCGA-55-6970	LUAD	TCGA	SKENN	DEG_APCC_KENBOX_2	0.1944
p.P31L	DO24421	LUAD	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1944
p.D14N	TCGA-AX-A1C9	UCEC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.1111
p.D14N	DO43098	UCEC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.D14H	TCGA-BA-4077	HNSC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.1111
p.D14H	DO15647	HNSC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.D14H	SIDM01133	Other Solid Cancers	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.R20S	TCGA-EY-A1GD	UCEC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.2778
p.R20S	DO42129	UCEC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.2778
p.R20S	SIDM00767	Small Cell Lung Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.2778
p.R20S	ACH-001136	Lung Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	0.2778
p.R20S	NCI-H187	lung	COSMIC	SKENN	DEG_APCC_KENBOX_2	0.2778
p.S22L	TCGA-GN-A8LK	SKCM	TCGA	SKENN	DEG_APCC_KENBOX_2	0.6556
p.S22L	DO51259	SKCM	ICGC	SKENN	DEG_APCC_KENBOX_2	0.6556
p.L15M	TCGA-KC-A4BR	PRAD	TCGA	SKENN	DEG_APCC_KENBOX_2	0.1389
p.L15M	DO228548	PRAD	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1389
p.L15M	DO219279	PRAD	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1389
p.T35K	DO228986	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.5278
p.F13L	DO229028	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.0833
p.S33R	DO229034	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1389
p.N25K	DO229038	LICA	ICGC	SKENN	DEG_APCC_KENBOX_2	0.6918
p.P31T	DO231758	LINC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29508	Serpin B3	DEG_APCC_KENBOX_2	22:26	SKENN	APC,CDC20,FZR1	0.5575	More...
Q02446	Transcription factor Sp4	DEG_APCC_KENBOX_2	112:116	SKENN	APC,CDC20,FZR1	0.8709	More...
Q86W56	Poly	DEG_APCC_KENBOX_2	98:102	SKENN	APC,CDC20,FZR1	0.9861	More...
Q9BXS6	Nucleolar and spindle-associated protein 1	DEG_APCC_KENBOX_2	383:387	SKENN	APC,CDC20,FZR1	0.7978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons