DegronMD - Q86W56(PARG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q106E	TCGA-37-A5EN	LUSC	TCGA	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2222
p.Q106E	DO223720	LUSC	ICGC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2222
p.D22G	TCGA-B5-A0JR	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7198
p.D22G	DO41791	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7198
p.D464G	TCGA-CA-6717	COAD	TCGA	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.2222
p.D464G	DO8264	COAD	ICGC	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.2222
p.L20V	TCGA-EO-A22U	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.6765
p.L20V	DO43755	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.6765
p.D90N	TCGA-F5-6814	READ	TCGA	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.D90N	DO36556	READ	ICGC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.V95A	TCGA-L5-A8NS	ESCA	TCGA	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.25
p.E454K	DO222640	BTCA	ICGC	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation altering degron motif	0.7022
p.F470L	DO231031	LUSC	ICGC	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.0556
p.H446Y	SIDM02064	Colorectal Carcinoma	GDSC	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.1111
p.M110I	SIDM00594	Acute Myeloid Leukemia	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.M110I	SIDM00599	Osteosarcoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.M110I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.M110I	SIDM00574	Glioblastoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.M110I	SIDM00580	Acute Myeloid Leukemia	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.M110I	SIDM00989	Bladder Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.S95G	SIDM00386	Ewing's Sarcoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.25
p.S95G	SIDM00515	Melanoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.25
p.P9L	SIDM00517	Head and Neck Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.P9L	SIDM00195	Ewing's Sarcoma	GDSC	AATTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.L96F	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.L96F	SIDM00849	Kidney Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.2778
p.R105I	SIDM00580	Acute Myeloid Leukemia	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.25
p.E100A	SIDM00118	Colorectal Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation altering degron motif	0.7701
p.S112Y	SIDM01611	Endometrial Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation blocking phosphorylation signal	0.5
p.W92C	ACH-000911	Gastric Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1667
p.L446M	ACH-000966	Ovarian Cancer	CCLE	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.1111
p.D90A	ACH-000978	Endometrial/Uterine Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	98:102	Mutation rewiring degron network	0.1111
p.N457K	ACH-000984	Endometrial/Uterine Cancer	CCLE	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation altering degron motif	0.6918
p.R470L	NCI-H1793	lung	COSMIC	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.0556
p.P444Q	LS-411N	large intestine	COSMIC	LGTPIEE	DEG_SCF_FBW7_2	454:460	Mutation rewiring degron network	0.0556

Kaplan plot for PARG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARG

UniProt ID: Q86W56

Entrez ID: 670

Protein name: Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PARG in