DegronMD

Uniprot ID: Q86W56

Source protein: Poly

Source gene: PARG

Class: DEG_SCF_FBW7_2

Location: 454:460

E3 ligase: FBXW7

DEGRON score: 0.5243

ASA_SCORE: 51.8714

COIL: 0.4841

CONS_SCORE: 0.2896

DSS_SCORE: 0.4748

HELIX: 0.4376

FCONS_SCORE: 1.0507

RIG_SCORE: 0.7678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D464G	TCGA-CA-6717	COAD	TCGA	LGTPIEE	DEG_SCF_FBW7_2	0.2222
p.D464G	DO8264	COAD	ICGC	LGTPIEE	DEG_SCF_FBW7_2	0.2222
p.E454K	DO222640	BTCA	ICGC	LGTPIEE	DEG_SCF_FBW7_2	0.7022
p.F470L	DO231031	LUSC	ICGC	LGTPIEE	DEG_SCF_FBW7_2	0.0556
p.H446Y	SIDM02064	Colorectal Carcinoma	GDSC	LGTPIEE	DEG_SCF_FBW7_2	0.1111
p.L446M	ACH-000966	Ovarian Cancer	CCLE	LGTPIEE	DEG_SCF_FBW7_2	0.1111
p.N457K	ACH-000984	Endometrial/Uterine Cancer	CCLE	LGTPIEE	DEG_SCF_FBW7_2	0.6918
p.R470L	NCI-H1793	lung	COSMIC	LGTPIEE	DEG_SCF_FBW7_2	0.0556
p.P444Q	LS-411N	large_intestine	COSMIC	LGTPIEE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86W56	Poly	DEG_SCF_FBW7_2	454:460	LGTPIEE	FBXW7	0.5243	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons