DegronMD

Uniprot ID: Q86W56

Source protein: Poly

Source gene: PARG

Class: DEG_APCC_KENBOX_2

Location: 98:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9861

ASA_SCORE: 103.92

COIL: 0.733

CONS_SCORE: 0.2696

DSS_SCORE: 0.5594

HELIX: 0.2316

FCONS_SCORE: 1.0038

RIG_SCORE: 0.6651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q106E	TCGA-37-A5EN	LUSC	TCGA	SKENN	DEG_APCC_KENBOX_2	0.2222
p.Q106E	DO223720	LUSC	ICGC	SKENN	DEG_APCC_KENBOX_2	0.2222
p.D90N	TCGA-F5-6814	READ	TCGA	SKENN	DEG_APCC_KENBOX_2	0.1111
p.D90N	DO36556	READ	ICGC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.V95A	TCGA-L5-A8NS	ESCA	TCGA	SKENN	DEG_APCC_KENBOX_2	0.25
p.M110I	SIDM00594	Acute Myeloid Leukemia	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.M110I	SIDM00599	Osteosarcoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.M110I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.M110I	SIDM00574	Glioblastoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.M110I	SIDM00580	Acute Myeloid Leukemia	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.M110I	SIDM00989	Bladder Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.1111
p.S95G	SIDM00386	Ewing's Sarcoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.25
p.S95G	SIDM00515	Melanoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.25
p.L96F	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.2778
p.L96F	SIDM00849	Kidney Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.2778
p.R105I	SIDM00580	Acute Myeloid Leukemia	GDSC	SKENN	DEG_APCC_KENBOX_2	0.25
p.E100A	SIDM00118	Colorectal Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.7701
p.S112Y	SIDM01611	Endometrial Carcinoma	GDSC	SKENN	DEG_APCC_KENBOX_2	0.5
p.W92C	ACH-000911	Gastric Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	0.1667
p.D90A	ACH-000978	Endometrial/Uterine Cancer	CCLE	SKENN	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29508	Serpin B3	DEG_APCC_KENBOX_2	22:26	SKENN	APC,CDC20,FZR1	0.5575	More...
Q02446	Transcription factor Sp4	DEG_APCC_KENBOX_2	112:116	SKENN	APC,CDC20,FZR1	0.8709	More...
Q86W56	Poly	DEG_APCC_KENBOX_2	98:102	SKENN	APC,CDC20,FZR1	0.9861	More...
Q9BXS6	Nucleolar and spindle-associated protein 1	DEG_APCC_KENBOX_2	383:387	SKENN	APC,CDC20,FZR1	0.7978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons