DegronMD

Uniprot ID: Q9BXS6

Source protein: Nucleolar and spindle-associated protein 1

Source gene: NUSAP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 161:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9866

ASA_SCORE: 98.6143

COIL: 0.8364

CONS_SCORE: 0.4308

DSS_SCORE: 0.6561

HELIX: 0.0839

FCONS_SCORE: 1.0838

RIG_SCORE: 0.6449

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L164I	TCGA-AJ-A5DW	UCEC	TCGA	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.6063
p.L164I	DO50075	UCEC	ICGC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.6063
p.D167Y	TCGA-G2-A2EO	BLCA	TCGA	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D166Y	DO456	BLCA	ICGC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.7325
p.R152T	DO222744	ESCA	ICGC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K161R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K161R	NCI-H2342	lung	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K155R	SIDM01377	Ovarian Carcinoma	GDSC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H169Y	ACH-000680	Colon/Colorectal Cancer	CCLE	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.7222
p.H169Y	SW948	large_intestine	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.7222
p.G173E	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H177Y	SW948	large_intestine	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.K160R	NCI-H2342	lung	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G172E	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G158E	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	KKSLYTD	LIG_APCC_ABBAyCdc20_2	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXS6	Nucleolar and spindle-associated protein 1	LIG_APCC_ABBAyCdc20_2	161:167	KKSLYTD	APC,CDC20,FZR1	0.9866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons