DegronMD

Uniprot ID: Q02446

Source protein: Transcription factor Sp4

Source gene: SP4

Class: DEG_SCF_FBW7_1

Location: 772:778

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 77.5143

COIL: 0.8641

CONS_SCORE: 0.3371

DSS_SCORE: 0.6179

HELIX: 0.0311

FCONS_SCORE: 1.0755

RIG_SCORE: 0.6743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N780S	TCGA-12-0688	GBM	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.2778
p.N780S	DO11088	GBM	ICGC	PATPNVS	DEG_SCF_FBW7_1	0.2778
p.T779N	TCGA-18-3416	LUSC	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.3056
p.T779N	DO26423	LUSC	ICGC	PATPNVS	DEG_SCF_FBW7_1	0.3056
p.S770L	TCGA-AA-A010	COAD	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	TCGA-AX-A06F	UCEC	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	TCGA-B5-A11N	UCEC	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	TCGA-EO-A22U	UCEC	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	DO41752	UCEC	ICGC	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	DO43755	UCEC	ICGC	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	DO41458	UCEC	ICGC	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.S770L	ACH-001991	Primary	CCLE	PATPNVS	DEG_SCF_FBW7_1	0.7222
p.E782K	TCGA-E7-A6ME	BLCA	TCGA	PATPNVS	DEG_SCF_FBW7_1	0.2222
p.E782K	DO51874	BLCA	ICGC	PATPNVS	DEG_SCF_FBW7_1	0.2222
p.Q768E	ACH-001652	Endometrial/Uterine Cancer	CCLE	PATPNVS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02446	Transcription factor Sp4	DEG_SCF_FBW7_1	772:778	PATPNVS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons