DegronMD

Uniprot ID: Q02446

Source protein: Transcription factor Sp4

Source gene: SP4

Class: DEG_SPOP_SBC_1

Location: 372:376

E3 ligase: SPOP

DEGRON score: 0.9419

ASA_SCORE: 77.98

COIL: 0.6738

CONS_SCORE: 0.3504

DSS_SCORE: 0.7558

HELIX: 0.264

FCONS_SCORE: 1.1186

RIG_SCORE: 0.6028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P365A	TCGA-EJ-5507	PRAD	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1389
p.P365A	DO36257	PRAD	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.A372G	DO50934	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.754
p.A372T	DO23440	LINC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.7139
p.N385D	SIDM01314	Colorectal Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.0833
p.M383I	SIDM02021	Esophageal Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.S362P	SIDM00845	Burkitt's Lymphoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24394	Interleukin-4 receptor subunit alpha	DEG_SPOP_SBC_1	802:806	AQSSS	SPOP	0.9859	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	28:32	AQSSS	SPOP	0.7543	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	372:376	AQSSS	SPOP	0.9419	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2384:2388	AQSSS	SPOP	0.8066	More...
Q13616	Cullin-1	DEG_SPOP_SBC_1	412:416	AQSSS	SPOP	0.5305	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	381:385	AQSSS	SPOP	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons