IL4R
UniProt ID: P24394
Entrez ID: 3566
Protein name: Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. ...
FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}.
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GO - Biological processes (BP):
cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; ovulation [GO:0030728]; positive regulation of chemok...
cytokine-mediated signaling pathway [GO:0019221]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; ovulation [GO:0030728]; positive regulation of chemokine production [GO:0032722]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of macrophage activation [GO:0043032]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of cell population proliferation [GO:0042127]; response to estrogen [GO:0043627]; response to odorant [GO:1990834]; signal transduction [GO:0007165]
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GO - Molecular function (MF):
cytokine receptor activity [GO:0004896]; interleukin-4 receptor activity [GO:0004913]...
cytokine receptor activity [GO:0004896]; interleukin-4 receptor activity [GO:0004913]
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GO - Cellular component (CC):
centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]...
centriolar satellite [GO:0034451]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
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IL4R
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Kaplan plot for IL4R in
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*NOTE: the Kaplan plots were collected from OncoLnc