DegronMD

Uniprot ID: Q9C0F0

Source protein: Putative Polycomb group protein ASXL3

Source gene: ASXL3

Class: DEG_SPOP_SBC_1

Location: 381:385

E3 ligase: SPOP

DEGRON score: 0.9526

ASA_SCORE: 79.46

COIL: 0.8472

CONS_SCORE: 0.2993

DSS_SCORE: 0.6069

HELIX: 0.059

FCONS_SCORE: 0.9591

RIG_SCORE: 0.5896

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N377K	TCGA-05-4382	LUAD	TCGA	AQSSS	DEG_SPOP_SBC_1	0.2222
p.N377K	DO24900	LUAD	ICGC	AQSSS	DEG_SPOP_SBC_1	0.2222
p.T374S	TCGA-56-8305	LUSC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1389
p.T374S	DO223725	LUSC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.S385Y	TCGA-B5-A0JY	UCEC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.712
p.S385Y	TCGA-CA-6717	COAD	TCGA	AQSSS	DEG_SPOP_SBC_1	0.712
p.S385Y	DO8264	COAD	ICGC	AQSSS	DEG_SPOP_SBC_1	0.712
p.S385Y	DO43041	UCEC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.712
p.S386L	TCGA-FR-A7U9	SKCM	TCGA	AQSSS	DEG_SPOP_SBC_1	0.3056
p.S386L	DO48546	SKCM	ICGC	AQSSS	DEG_SPOP_SBC_1	0.3056
p.S395C	TCGA-GD-A2C5	BLCA	TCGA	AQSSS	DEG_SPOP_SBC_1	0.0556
p.S395C	DO496	BLCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.0556
p.G391C	TCGA-QK-A6VC	HNSC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1667
p.G391C	DO219056	HNSC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1667
p.G388W	TCGA-QK-A8Z7	HNSC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.25
p.G388W	DO52096	HNSC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.25
p.C387F	DO233230	GACA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.2778
p.S383R	DO233874	GACA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.7427
p.G380R	DO222843	MELA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.3056
p.S395F	DO218874	SKCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.0556
p.L392F	SIDM00545	Melanoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.L392F	ACH-000987	Skin Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	0.1389
p.L392F	Mewo	skin	COSMIC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.Q382R	SIDM00179	Melanoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.6218
p.Q382R	ACH-002165	Skin Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	0.6218
p.Q382R	MZ2-MEL	skin	COSMIC	AQSSS	DEG_SPOP_SBC_1	0.6218
p.K371M	SIDM01681	Non-Cancerous	GDSC	AQSSS	DEG_SPOP_SBC_1	0.1667
p.K371M	ACH-002362	Non-Cancerous	CCLE	AQSSS	DEG_SPOP_SBC_1	0.1667
p.L392H	SIDM01617	Endometrial Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.L392H	ACH-000994	Endometrial/Uterine Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	0.1389
p.T373I	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.1111
p.T373I	ACH-000553	Lung Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24394	Interleukin-4 receptor subunit alpha	DEG_SPOP_SBC_1	802:806	AQSSS	SPOP	0.9859	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	28:32	AQSSS	SPOP	0.7543	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	372:376	AQSSS	SPOP	0.9419	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2384:2388	AQSSS	SPOP	0.8066	More...
Q13616	Cullin-1	DEG_SPOP_SBC_1	412:416	AQSSS	SPOP	0.5305	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	381:385	AQSSS	SPOP	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AQSSS

Degron related mutations and impact score

Drug responses associated with ASXL3 mutations

All proteins holding degron of AQSSS