DegronMD

Uniprot ID: Q13616

Source protein: Cullin-1

Source gene: CUL1

Class: DEG_SPOP_SBC_1

Location: 412:416

E3 ligase: SPOP

DEGRON score: 0.5305

ASA_SCORE: 69.2

COIL: 0.8434

CONS_SCORE: 0.2919

DSS_SCORE: 0.374

HELIX: 0.1212

FCONS_SCORE: 0.5558

RIG_SCORE: 0.6973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N406H	TCGA-05-4250	LUAD	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1667
p.N406H	DO24457	LUAD	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1667
p.N405S	TCGA-17-Z051	LUAD	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1389
p.A423D	TCGA-2W-A8YY	CESC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1389
p.A423D	DO223732	CESC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1389
p.E420K	TCGA-CU-A3YL	BLCA	TCGA	AQSSS	DEG_SPOP_SBC_1	0.2222
p.E420K	DO834	BLCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.2222
p.P419L	TCGA-EB-A3XB	SKCM	TCGA	AQSSS	DEG_SPOP_SBC_1	0.25
p.P419L	DO37856	SKCM	ICGC	AQSSS	DEG_SPOP_SBC_1	0.25
p.R424Q	TCGA-EO-A22R	UCEC	TCGA	AQSSS	DEG_SPOP_SBC_1	0.1111
p.R424Q	DO42713	UCEC	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1111
p.R424Q	SIDM02058	Esophageal Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	0.1111
p.S414T	DO233251	GACA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.6005
p.E420V	DO44832	LICA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.2222
p.R424P	DO27943	ORCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1111
p.R424P	ACH-000435	Endometrial/Uterine Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	0.1111
p.A407V	DO232761	PBCA	ICGC	AQSSS	DEG_SPOP_SBC_1	0.1944
p.S409C	NCI-H1793	lung	COSMIC	AQSSS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24394	Interleukin-4 receptor subunit alpha	DEG_SPOP_SBC_1	802:806	AQSSS	SPOP	0.9859	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	28:32	AQSSS	SPOP	0.7543	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	372:376	AQSSS	SPOP	0.9419	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2384:2388	AQSSS	SPOP	0.8066	More...
Q13616	Cullin-1	DEG_SPOP_SBC_1	412:416	AQSSS	SPOP	0.5305	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	381:385	AQSSS	SPOP	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons