DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
AQSSS
Uniprot ID:
Q12830
Source protein:
Nucleosome-remodeling factor subunit BPTF
Source gene:
BPTF
Class:
DEG_SPOP_SBC_1
Location:
2384:2388
E3 ligase:
SPOP
DEGRON score:
0.8066
ASA_SCORE:
86.76
COIL:
0.9328
CONS_SCORE:
0.3149
DSS_SCORE:
0.8328
HELIX:
0.0216
FCONS_SCORE:
0.9235
RIG_SCORE:
0.524
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S2393L
TCGA-EJ-7331
PRAD
TCGA
AQSSS
DEG_SPOP_SBC_1
0.1944
p.S2393L
DO36301
PRAD
ICGC
AQSSS
DEG_SPOP_SBC_1
0.1944
Drug responses associated with BPTF mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AQSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P24394
Interleukin-4 receptor subunit alpha
DEG_SPOP_SBC_1
802:806
AQSSS
SPOP
0.9859
More...
P50281
Matrix metalloproteinase-14
DEG_SPOP_SBC_1
28:32
AQSSS
SPOP
0.7543
More...
Q02446
Transcription factor Sp4
DEG_SPOP_SBC_1
372:376
AQSSS
SPOP
0.9419
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
2384:2388
AQSSS
SPOP
0.8066
More...
Q13616
Cullin-1
DEG_SPOP_SBC_1
412:416
AQSSS
SPOP
0.5305
More...
Q9C0F0
Putative Polycomb group protein ASXL3
DEG_SPOP_SBC_1
381:385
AQSSS
SPOP
0.9526
More...