DegronMD

Uniprot ID: Q02446

Source protein: Transcription factor Sp4

Source gene: SP4

Class: DEG_SPOP_SBC_1

Location: 183:187

E3 ligase: SPOP

DEGRON score: 0.896

ASA_SCORE: 50.36

COIL: 0.691

CONS_SCORE: 0.3934

DSS_SCORE: 0.4372

HELIX: 0.0692

FCONS_SCORE: 1.0958

RIG_SCORE: 0.7123

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S187L	TCGA-4Z-AA84	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.7667
p.S187L	DO218988	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7667
p.G176R	TCGA-BJ-A28S	THCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1389
p.G176R	DO48141	THCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1389
p.Q195E	TCGA-60-2714	LUSC	TCGA	PTSSS	DEG_SPOP_SBC_1	0.1111
p.Q195E	DO26530	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1111
p.Q197K	ACH-000961	Endometrial/Uterine Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.0556

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Drug responses associated with SP4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PTSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	DEG_SPOP_SBC_1	470:474	PTSSS	SPOP	0.9605	More...
Q05823	2-5A-dependent ribonuclease	DEG_SPOP_SBC_1	13:17	PTSSS	SPOP	0.9874	More...
Q4VCS5	Angiomotin	DEG_SPOP_SBC_1	211:215	PTSSS	SPOP	0.9988	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2626:2630	PTSSS	SPOP	0.9845	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	139:143	PTSSS	SPOP	0.948	More...
Q92934	Bcl2-associated agonist of cell death	DEG_SPOP_SBC_1	55:59	PTSSS	SPOP	0.7818	More...
Q9BUH8	Brain-enriched guanylate kinase-associated protein	DEG_SPOP_SBC_1	295:299	PTSSS	SPOP	0.9553	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	17:21	PTSSS	SPOP	0.8669	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	2379:2383	PTSSS	SPOP	0.9083	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1276:1280	PTSSS	SPOP	0.9503	More...
P50402	Emerin	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.9908	More...
O15353	Forkhead box protein N1	DEG_SPOP_SBC_1	566:570	PTSSS	SPOP	0.9933	More...
Q9Y5N1	Histamine H3 receptor	DEG_SPOP_SBC_1	303:307	PTSSS	SPOP	0.9912	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1874:1878	PTSSS	SPOP	0.8129	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	657:661	PTSSS	SPOP	0.9681	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	306:310	PTSSS	SPOP	0.9982	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	377:381	PTSSS	SPOP	0.9915	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SPOP_SBC_1	166:170	PTSSS	SPOP	0.9809	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	135:139	PTSSS	SPOP	0.9984	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	923:927	PTSSS	SPOP	0.9994	More...
O14795	Protein unc-13 homolog B	DEG_SPOP_SBC_1	255:259	PTSSS	SPOP	0.9982	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	742:746	PTSSS	SPOP	0.9157	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	1195:1199	PTSSS	SPOP	0.9915	More...
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SPOP_SBC_1	314:318	PTSSS	SPOP	0.9747	More...
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	833:837	PTSSS	SPOP	0.988	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSSS

Degron related mutations and impact score

Drug responses associated with SP4 mutations

All proteins holding degron of PTSSS