DegronMD - Q15911(ZFHX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M2372I	TCGA-09-2044	OV	TCGA	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.1944
p.M2372I	DO28923	OV	ICGC	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.1944
p.R2203H	TCGA-2W-A8YY	CESC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.R2203H	SIDM00216	Colorectal Carcinoma	GDSC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.R2203H	ACH-000989	Colon/Colorectal Cancer	CCLE	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.R2203H	SNU-175	large intestine	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.T547S	TCGA-34-2604	LUSC	TCGA	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.T547S	DO26433	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.Q2186L	TCGA-43-7656	LUSC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.1111
p.S2605L	TCGA-77-7337	LUSC	TCGA	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation altering degron motif	0.6556
p.S2605L	DO27445	LUSC	ICGC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation altering degron motif	0.6556
p.S1650C	TCGA-85-8354	LUSC	TCGA	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.2222
p.R545S	TCGA-99-8028	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.R545S	DO23561	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.K3683T	TCGA-A5-A1OF	UCEC	TCGA	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation substituting flanking lysine	0.25
p.A515S	TCGA-A5-A1OF	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7588
p.A515S	DO42568	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7588
p.P3127L	TCGA-AJ-A3EK	UCEC	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation rewiring degron network	0.1111
p.P3127L	DO41584	UCEC	ICGC	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation rewiring degron network	0.1111
p.A2371V	TCGA-AX-A1CE	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.1667
p.A2371V	TCGA-G4-6588	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.1667
p.P419S	TCGA-BF-A5EP	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.2778
p.P419S	DO223906	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.2778
p.T2384I	TCGA-BG-A18C	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.25
p.R2616K	TCGA-BQ-5878	KIRP	TCGA	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.1667
p.P3149L	TCGA-BR-8078	STAD	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation rewiring degron network	0.1389
p.P3149L	DO38288	STAD	ICGC	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation rewiring degron network	0.1389
p.A514T	TCGA-CD-A4MI	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514T	DO10582	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514T	DO47717	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.S1650Y	TCGA-CG-5733	STAD	TCGA	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.2222
p.P2787S	TCGA-D1-A17F	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.0833
p.D3684V	TCGA-D3-A5GR	SKCM	TCGA	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.1667
p.D3684V	DO47436	SKCM	ICGC	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.1667
p.I1645S	TCGA-D9-A6EC	SKCM	TCGA	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.0833
p.I1645S	DO50291	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.0833
p.A424D	TCGA-DU-6392	LGG	TCGA	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1389
p.A424D	DO22237	LGG	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1389
p.N1661S	TCGA-E6-A1LX	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.25
p.N1661S	DO41020	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.25
p.P3139L	TCGA-EE-A20C	SKCM	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation altering degron motif	0.7582
p.P419L	TCGA-EE-A2GS	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.2778
p.P419L	DO37465	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.2778
p.S557F	TCGA-EE-A2MR	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S557F	DO37819	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.S417L	TCGA-EK-A3GK	CESC	TCGA	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.7667
p.S417L	DO49964	CESC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.7667
p.P3688H	TCGA-FD-A5BX	BLCA	TCGA	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.2778
p.P3688H	DO44079	BLCA	ICGC	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.2778
p.T1657S	TCGA-FD-A62P	BLCA	TCGA	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation altering degron motif	0.6005
p.S409L	TCGA-FW-A3R5	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.3056
p.S409L	DO37406	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.3056
p.C3646Y	TCGA-G4-6302	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation rewiring degron network	0.1111
p.C3646Y	TCGA-G4-6302	COAD	TCGA	VTSSS	DEG_SPOP_SBC_1	3641:3645	Mutation rewiring degron network	0.3056
p.C3646Y	DO8778	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation rewiring degron network	0.1111
p.C3646Y	DO8778	COAD	ICGC	VTSSS	DEG_SPOP_SBC_1	3641:3645	Mutation rewiring degron network	0.3056
p.L403F	TCGA-GN-A4U8	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1389
p.L403F	DO47320	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1389
p.T3694I	TCGA-HU-8602	STAD	TCGA	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation altering degron motif	0.5966
p.S3146F	TCGA-L5-A4OI	ESCA	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation rewiring degron network	0.2222
p.E2200K	TCGA-NI-A4U2	LIHC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation altering degron motif	0.7022
p.L2785R	TCGA-QT-A5XP	PCPG	TCGA	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.I2189M	TCGA-R3-A69X	BLCA	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.1944
p.S544P	TCGA-VQ-A91K	STAD	TCGA	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.S544P	DO51785	STAD	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.H2191N	TCGA-ZB-A96M	THYM	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.Q2595E	TCGA-ZJ-AAXT	CESC	TCGA	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.0833
p.Q2595E	DO219758	CESC	ICGC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.0833
p.G2767R	DO227935	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.G2767R	SIDM00999	Bladder Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.G2767R	SIDM01619	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.G2767R	ACH-000973	Bladder Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.G2767R	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.G2767R	639-V	urinary tract	COSMIC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.R512T	DO219621	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.25
p.T3698M	DO222955	BTCA	ICGC	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.25
p.S544L	DO223571	CLLE	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.S544L	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.S544L	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.P2784S	DO7990	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1667
p.V539M	DO230312	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.V539M	SIDM00150	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.V539M	ACH-000299	Leukemia	CCLE	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.V539M	ACH-000969	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.V539M	KM12	large intestine	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.C517R	DO230326	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.8301
p.M3655I	DO222794	COCA	ICGC	VTSSS	DEG_SPOP_SBC_1	3641:3645	Mutation rewiring degron network	0.0556
p.E403D	DO50341	ESAD	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1389
p.G2782C	DO233903	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.2222
p.A515E	DO229026	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7701
p.A515E	DO229034	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7701
p.D505E	DO229006	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.0556
p.S529R	DO229009	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation blocking phosphorylation signal	0.5
p.N402K	DO229008	LICA	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1111
p.I2189V	DO50966	LICA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.1944
p.T2768S	DO23298	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1667
p.Q2781R	DO23128	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.25
p.P2774H	DO231700	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation altering degron motif	0.7694
p.S557Y	DO229238	LMS	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.Q2186K	DO230532	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.1111
p.A2368V	DO219153	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.0833
p.H1648Y	DO222843	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.1667
p.G2596S	DO35083	PACA	ICGC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.1111
p.S423N	DO232224	PBCA	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1667
p.S1648G	DO51078	PRAD	ICGC	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.1667
p.P422S	DO218863	SKCA	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1944
p.R525Q	DO50287	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525Q	DO223907	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525Q	DO219773	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525Q	DO41020	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R525Q	DO43971	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.R522H	DO51773	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.25
p.T2780I	DO47829	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.2778
p.G2600A	DO229173	THCA	ICGC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.2222
p.A2619V	DO229234	THCA	ICGC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.0833
p.G2597C	DO229250	THCA	ICGC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.1389
p.S3639L	DO234014	THCA	ICGC	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation rewiring degron network	0.3056
p.S3639L	DO234014	THCA	ICGC	VTSSS	DEG_SPOP_SBC_1	3641:3645	Mutation rewiring degron network	0.2778
p.A2387T	DO43186	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.1667
p.P420S	DO52402	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.25
p.A422T	DO42953	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1944
p.A422T	DO43971	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1944
p.G405E	DO41903	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation rewiring degron network	0.1944
p.A544T	DO41871	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.K2769T	DO42568	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1944
p.K416N	DO42713	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation altering degron motif	0.6918
p.T2608S	SIDM01313	Colorectal Carcinoma	GDSC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation altering degron motif	0.6005
p.S551C	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7541
p.P2787L	SIDM01169	Ovarian Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.0833
p.P2787L	ACH-000885	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.0833
p.P2787L	TOV-21G	ovary	COSMIC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.0833
p.T547P	SIDM00845	Burkitt's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.T547P	ACH-000786	Lymphoma	CCLE	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.S517G	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.6993
p.T1651M	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.25
p.T1651M	SIDM00881	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	1654:1658	Mutation rewiring degron network	0.25
p.D3699G	SIDM00680	Colorectal Carcinoma	GDSC	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.2222
p.D3699G	ACH-000957	Colon/Colorectal Cancer	CCLE	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.2222
p.D3699G	LS-180	large intestine	COSMIC	DSGLTS	DEG_SCF_TRCP1_1	3690:3695	Mutation rewiring degron network	0.2222
p.P2385L	SIDM00120	Prostate Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.2222
p.P2385L	ACH-000979	Prostate Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.2222
p.P2385L	DU-145	prostate	COSMIC	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.2222
p.S556C	SIDM00643	Non-Cancerous	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.V2783A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1944
p.V2783A	ACH-001669	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1944
p.V2783A	ACH-002238	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1944
p.V2783A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1944
p.A524T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1944
p.A524T	ACH-000893	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1944
p.A524T	NCI-H1651	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1944
p.S3638F	SIDM00864	Cervical Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation altering degron motif	0.7982
p.S3638F	ACH-001341	Cervical Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation altering degron motif	0.7982
p.S3638F	DoTc2-4510	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation altering degron motif	0.7982
p.K3628T	SIDM00279	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation substituting flanking lysine	0.2778
p.K3628T	ACH-000225	Gastric Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation substituting flanking lysine	0.2778
p.K3628T	ECC12	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation substituting flanking lysine	0.2778
p.A514V	SIDM00077	Oral Cavity Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514V	ACH-001331	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.A514V	BICR10	upper aerodigestive tract	COSMIC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.3056
p.G546D	SIDM01608	Endometrial Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2778
p.G546D	ACH-000990	Endometrial/Uterine Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2778
p.I2764T	SIDM01757	Bladder Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.0556
p.I2764T	ACH-000741	Bladder Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.0556
p.T2608A	SIDM01504	Small Cell Lung Carcinoma	GDSC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation altering degron motif	0.6028
p.T2376M	SIDM01619	Endometrial Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.3056
p.T2376M	ACH-000984	Endometrial/Uterine Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation rewiring degron network	0.3056
p.S425C	ACH-000299	Leukemia	CCLE	VLKTPITS	DEG_SCF_FBW7_1	410:417	Mutation blocking phosphorylation signal	0.5556
p.P3633S	ACH-000529	Non-Cancerous	CCLE	PLSSS	DEG_SPOP_SBC_1	3634:3638	Mutation rewiring degron network	0.3056
p.P3633S	ACH-000529	Non-Cancerous	CCLE	VTSSS	DEG_SPOP_SBC_1	3641:3645	Mutation rewiring degron network	0.1111
p.N538K	ACH-001277	Sarcoma	CCLE	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.P2377S	ACH-001627	Prostate Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	2377:2381	Mutation altering degron motif	0.6752
p.A548S	ACH-002026	Endometrial/Uterine Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7588
p.M562I	SNU-449	liver	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.M562I	BFTC-905	urinary tract	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.M562I	KO52	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.M562I	NCC010	kidney	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.M562I	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.M562I	KMRC-20	kidney	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.A2203V	RF-48	stomach	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.P3127S	WM793B	skin	COSMIC	PGFTPSNT	DEG_SCF_FBW7_1	3135:3142	Mutation rewiring degron network	0.1111
p.R525L	ES5	bone	COSMIC	AGSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1667
p.D2785G	LS-180	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.1389
p.C2620W	NCI-H2172	lung	COSMIC	PSTPTST	DEG_SCF_FBW7_1	2604:2610	Mutation rewiring degron network	0.0556
p.P2191L	PE/CA-PJ15	upper aerodigestive tract	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2194:2200	Mutation rewiring degron network	0.25
p.L559F	A549	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFHX3

UniProt ID: Q15911

Entrez ID: 463

Protein name: Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFHX3 in