DegronMD

Uniprot ID: Q15911

Source protein: Zinc finger homeobox protein 3

Source gene: ZFHX3

Class: LIG_APCC_ABBAyCdc20_2

Location: 2194:2200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9105

ASA_SCORE: 105.4143

COIL: 0.5569

CONS_SCORE: 1

DSS_SCORE: 0.4464

HELIX: 0.4211

FCONS_SCORE: 1.06

RIG_SCORE: 0.8213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2203H	TCGA-2W-A8YY	CESC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.R2203H	SIDM00216	Colorectal Carcinoma	GDSC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.R2203H	ACH-000989	Colon/Colorectal Cancer	CCLE	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.R2203H	SNU-175	large_intestine	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q2186L	TCGA-43-7656	LUSC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E2200K	TCGA-NI-A4U2	LIHC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.7022
p.I2189M	TCGA-R3-A69X	BLCA	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H2191N	TCGA-ZB-A96M	THYM	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.I2189V	DO50966	LICA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q2186K	DO230532	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A2203V	RF-48	stomach	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.P2191L	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15911	Zinc finger homeobox protein 3	LIG_APCC_ABBAyCdc20_2	2194:2200	RNTLFKE	APC,CDC20,FZR1	0.9105	More...
Q86UP3	Zinc finger homeobox protein 4	LIG_APCC_ABBAyCdc20_2	2133:2139	RNTLFKE	APC,CDC20,FZR1	0.6904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons