DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: LIG_APCC_ABBAyCdc20_2

Location: 2133:2139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6904

ASA_SCORE: 106.3286

COIL: 0.5344

CONS_SCORE: 0.9176

DSS_SCORE: 0.4041

HELIX: 0.4516

FCONS_SCORE: 1.0774

RIG_SCORE: 0.8269

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2145S	TCGA-21-1083	LUSC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A2146D	TCGA-30-1855	OV	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P2132T	TCGA-53-7624	LUAD	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P2132T	TCGA-CG-5723	STAD	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D2149E	TCGA-68-7757	LUSC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R2131H	TCGA-AP-A051	UCEC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S2127Y	TCGA-B5-A0JY	UCEC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S2127Y	DO40884	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S2127Y	DO42400	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L2144P	TCGA-BR-7851	STAD	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R2133L	TCGA-EM-A2CK	THCA	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.8428
p.R2133W	TCGA-L5-A8NS	ESCA	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.8634
p.G2141C	DO470	BLCA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.N2125S	DO225296	BRCA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S2129G	DO219894	DLBC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3333
p.E2138K	DO233193	GACA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E2138K	DO47303	SKCM	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.7022
p.Q2132H	DO24920	LUAD	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q2132H	DO41020	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q2134K	DO25020	LUAD	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.6944
p.Q2132E	DO230965	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q2132E	DO224599	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E2131K	DO231132	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E2131K	DO42817	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V2146I	DO231207	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D2123E	DO26886	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L2142I	DO41235	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.S2140Y	DO42793	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N2126T	DO42713	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A2146V	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A2146V	ACH-000647	Esophageal Cancer	CCLE	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A2146V	TE-1	oesophagus	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.F2123I	ACH-001111	Lymphoma	CCLE	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E2130K	HCC-78	lung	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15911	Zinc finger homeobox protein 3	LIG_APCC_ABBAyCdc20_2	2194:2200	RNTLFKE	APC,CDC20,FZR1	0.9105	More...
Q86UP3	Zinc finger homeobox protein 4	LIG_APCC_ABBAyCdc20_2	2133:2139	RNTLFKE	APC,CDC20,FZR1	0.6904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RNTLFKE

Degron related mutations and impact score

Drug responses associated with ZFHX4 mutations

All proteins holding degron of RNTLFKE