DegronMD - Q86UP3(ZFHX4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P3119A	TCGA-05-4382	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.S2383Y	TCGA-06-5416	GBM	TCGA	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2222
p.S511L	TCGA-06-6701	GBM	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.7667
p.S511L	DO13264	GBM	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.7667
p.M2823I	TCGA-17-Z015	LUAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.0556
p.Q505K	TCGA-17-Z055	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2222
p.I2810V	TCGA-18-3416	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7076
p.S3116Y	TCGA-21-1081	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.1389
p.R2145S	TCGA-21-1083	LUSC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1667
p.Q1073H	TCGA-2F-A9KO	BLCA	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7582
p.A2146D	TCGA-30-1855	OV	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1389
p.R1067L	TCGA-33-4538	LUSC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.8428
p.P3119S	TCGA-34-2600	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119L	TCGA-34-2600	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.A386T	TCGA-34-5928	LUSC	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7139
p.A386T	TCGA-WS-AB45	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7139
p.A386T	DO51734	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7139
p.A386T	DO27461	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7139
p.G521S	TCGA-43-2578	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1111
p.G521S	DO26662	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1111
p.L1062Q	TCGA-44-2657	LUAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7765
p.T388S	TCGA-44-2662	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.6005
p.T388S	DO26290	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.6005
p.L3450I	TCGA-44-5644	LUAD	TCGA	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation altering degron motif	0.7174
p.L3450I	TCGA-AP-A0LM	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation altering degron motif	0.7174
p.F2800I	TCGA-49-AARE	LUAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.T522N	TCGA-50-5930	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0833
p.T522N	DO25189	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0833
p.P2132T	TCGA-53-7624	LUAD	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.P2132T	TCGA-CG-5723	STAD	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.P3119Q	TCGA-55-6983	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119Q	TCGA-GN-A262	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.G409W	TCGA-55-7573	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.G409W	DO23675	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.G2386A	TCGA-55-7907	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.3056
p.A386V	TCGA-55-8097	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.5825
p.A386V	DO230311	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.5825
p.A386V	DO25699	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.5825
p.S387C	TCGA-55-8302	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.643
p.S387C	DO45312	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.643
p.H1065N	TCGA-56-6546	LUSC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7423
p.G2819R	TCGA-56-7731	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.S389L	TCGA-5M-AAT6	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7667
p.S389L	DO223703	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7667
p.D2799Y	TCGA-60-2709	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.G378V	TCGA-67-3771	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1111
p.G378V	DO25797	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1111
p.D2149E	TCGA-68-7757	LUSC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.0556
p.S432Y	TCGA-73-4668	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.0556
p.S432Y	DO23961	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.0556
p.P509S	TCGA-73-A9RS	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.6752
p.P509S	DO51193	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.6752
p.P509S	DO37418	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.6752
p.E2822G	TCGA-77-8139	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.0833
p.V1063E	TCGA-77-8140	LUSC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7693
p.P2395H	TCGA-78-7150	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2222
p.T2808K	TCGA-85-6560	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7306
p.P501T	TCGA-98-A539	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1111
p.P501T	DO52022	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1111
p.S3116C	TCGA-99-8032	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.1389
p.A3455D	TCGA-A5-A0G1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.3056
p.C1052R	TCGA-A5-A0G2	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0833
p.G1076V	TCGA-A5-A0G2	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2778
p.D2799N	TCGA-A5-A0GP	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.D2799N	TCGA-DK-A6AW	BLCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.S1068L	TCGA-A5-A2K5	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	TCGA-AG-A002	READ	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	TCGA-AP-A056	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	TCGA-BS-A0UF	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	TCGA-EO-A22U	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	TCGA-EO-A22X	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	TCGA-FI-A2D0	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.S1068L	ACH-001567	Skin Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7667
p.V1058F	TCGA-AA-3875	COAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.25
p.S513I	TCGA-AJ-A3EK	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.7341
p.S513I	DO41584	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.7341
p.R2131H	TCGA-AP-A051	UCEC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.2778
p.S2805L	TCGA-AP-A056	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.3056
p.S2805L	TCGA-CA-6718	COAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.3056
p.S2805L	TCGA-EE-A3JD	SKCM	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.3056
p.S2805L	TCGA-EY-A1GI	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.3056
p.L502I	TCGA-AX-A2HC	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1389
p.L502I	DO41572	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1389
p.S2127Y	TCGA-B5-A0JY	UCEC	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1667
p.S2127Y	DO40884	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1667
p.S2127Y	DO42400	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1667
p.F517C	TCGA-B5-A11N	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2222
p.F517C	TCGA-VQ-A91X	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2222
p.F517C	DO51790	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2222
p.F517C	DO41458	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.2222
p.L1062M	TCGA-B5-A1MR	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.711
p.L1062M	TCGA-E6-A1LX	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.711
p.R1078W	TCGA-B5-A1MR	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.R1078W	SIDM00917	Acute Myeloid Leukemia	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.R1078W	ACH-002218	Leukemia	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.R1078W	CESS	haematopoietic and lymphoid tissue	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.L408M	TCGA-B5-A3FA	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1389
p.L408M	DO52402	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1389
p.R1078Q	TCGA-BF-A5EO	SKCM	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.R1078Q	TCGA-GF-A6C9	SKCM	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.G2816R	TCGA-BG-A222	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.G2816R	TCGA-ZF-AA4U	BLCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.G2816R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.G2816R	ACH-001638	Lymphoma	CCLE	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.G2816R	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.K383T	TCGA-BK-A6W3	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation substituting flanking lysine	0.3611
p.K383T	DO50076	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation substituting flanking lysine	0.3611
p.S428P	TCGA-BR-4257	STAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.S428P	DO38683	STAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.A2809T	TCGA-BR-6452	STAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7139
p.A2809T	TCGA-YD-A9TA	SKCM	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7139
p.L2144P	TCGA-BR-7851	STAD	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation substituting flanking lysine	0.3056
p.E2802D	TCGA-BS-A0UV	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2222
p.E2802D	TCGA-D1-A17Q	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2222
p.E2802D	TCGA-EO-A22U	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2222
p.L1060F	TCGA-CF-A47X	BLCA	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.3056
p.T1056A	TCGA-CG-5717	STAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1944
p.T1055S	TCGA-D1-A17F	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1667
p.V423I	TCGA-D1-A2G0	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.3056
p.V423I	DO43049	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.3056
p.P3122Q	TCGA-D3-A1QA	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.3056
p.N2820T	TCGA-DD-A4NQ	LIHC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.T2808M	TCGA-DF-A2KN	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7423
p.A392T	TCGA-E6-A1LX	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.A392T	DO41020	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G3120R	TCGA-EE-A181	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.25
p.P3443S	TCGA-EE-A2GB	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.1389
p.G397E	TCGA-EE-A2M5	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1389
p.G397E	DO222423	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1389
p.G397E	DO222753	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1389
p.G397E	DO37425	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1389
p.R2133L	TCGA-EM-A2CK	THCA	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation altering degron motif	0.8428
p.K516T	TCGA-EO-A3AV	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation substituting flanking lysine	0.3611
p.K516T	DO52412	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation substituting flanking lysine	0.3611
p.S426G	TCGA-FI-A2D5	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.2222
p.S426G	DO41331	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.2222
p.K1070N	TCGA-FI-A2D5	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.6918
p.T1055I	TCGA-FR-A3YN	SKCM	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1667
p.G2386E	TCGA-FS-A1ZK	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.3056
p.G384R	TCGA-FS-A4F0	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G384R	TCGA-FW-A3R5	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G384R	TCGA-YG-AA3N	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G384R	DO37891	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G384R	DO37406	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G384R	DO51298	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.E2818K	TCGA-FS-A4F5	SKCM	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation substituting flanking lysine	0.3056
p.E2818K	TCGA-FZ-5921	PAAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation substituting flanking lysine	0.3056
p.E2818K	SIDM01175	Other Sarcomas	GDSC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation substituting flanking lysine	0.3056
p.E2818K	ACH-002309	Sarcoma	CCLE	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation substituting flanking lysine	0.3056
p.E2818K	SW684	soft tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation substituting flanking lysine	0.3056
p.A2813S	TCGA-G4-6295	COAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7588
p.P3122S	TCGA-GN-A266	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.3056
p.G3458W	TCGA-GN-A26C	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.2222
p.A2378S	TCGA-HZ-A77Q	PAAD	TCGA	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.0833
p.K1070T	TCGA-IG-A4QS	ESCA	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7306
p.Q1084K	TCGA-J2-8194	LUAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0556
p.Q1084K	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0556
p.Q1084K	ACH-000481	Lung Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0556
p.Q1084K	NCI-H2170	lung	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0556
p.R2133W	TCGA-L5-A8NS	ESCA	TCGA	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation altering degron motif	0.8634
p.D2817Y	TCGA-LN-A49K	ESCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2222
p.D2817Y	TCGA-R6-A8W5	ESCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2222
p.G410W	TCGA-NJ-A4YF	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1944
p.G410W	DO218940	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1944
p.Q1081K	TCGA-NJ-A55R	LUAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1389
p.S422F	TCGA-NK-A5CT	LUSC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7982
p.S422F	DO219209	LUSC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7982
p.P3443A	TCGA-O2-A52N	LUSC	TCGA	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.1389
p.R1067S	TCGA-PG-A6IB	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7427
p.P2390S	TCGA-WE-AAA0	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation altering degron motif	0.6752
p.S424F	TCGA-YG-AA3O	SKCM	TCGA	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.2778
p.S424F	DO51299	SKCM	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.2778
p.S3117F	TCGA-YU-A912	TGCT	TCGA	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.1667
p.P2804R	DO51892	BLCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2778
p.L2820I	DO48566	BLCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.L2820I	DO8842	COAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.L2820I	DO219919	DLBC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.L2820I	DO42400	UCEC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1389
p.G2141C	DO470	BLCA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.2778
p.I420V	DO52617	BOCA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.5965
p.P376L	DO225132	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P376L	DO27893	ORCA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P2392R	DO225322	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.3056
p.N2125S	DO225296	BRCA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1111
p.P2395S	DO224765	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2222
p.D2816N	DO228471	BRCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.D2816N	DO37711	SKCM	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.25
p.L2800V	DO1902	BRCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.E1064G	DO10590	COAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.6087
p.G3130A	DO44094	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.25
p.L2823P	DO9972	COAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.0556
p.S2393F	DO8240	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2778
p.S2393F	DO25927	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2778
p.L2800P	DO227779	COCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.C2815Y	DO224639	COCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2778
p.D499Y	DO222762	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0556
p.Q2389R	DO222874	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation altering degron motif	0.7329
p.S3456L	DO222884	COCA	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.2778
p.S3456L	DO228142	PBCA	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.2778
p.S3456L	DO50075	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.2778
p.S2129G	DO219894	DLBC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation substituting flanking lysine	0.3333
p.L2823H	DO234230	ESAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.0556
p.Q1055R	DO234245	ESAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1667
p.A2384G	DO234308	ESAD	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.25
p.S523L	DO48210	ESCA	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0556
p.N3463S	DO228631	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.0833
p.H427N	DO233189	GACA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1944
p.S426R	DO233189	GACA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.2222
p.Q2397E	DO233211	GACA	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1667
p.Q2397E	DO52066	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1667
p.E2138K	DO233193	GACA	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation altering degron motif	0.7022
p.E2138K	DO47303	SKCM	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation altering degron motif	0.7022
p.E2796A	DO233746	GACA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.0556
p.E3134K	DO233873	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.1389
p.A2384T	DO14286	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.25
p.A2384T	DO43306	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.25
p.S387I	DO229031	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.623
p.G521V	DO44706	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1111
p.P2401L	DO52193	LIHC	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.0556
p.P2401L	DO45319	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.0556
p.D1076V	DO24527	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2778
p.Q1055K	DO218947	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1667
p.I1071N	DO25426	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.6169
p.I1071N	DO38352	STAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.6169
p.Q1058K	DO23971	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.25
p.Q1058K	NCI-H2170	lung	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.25
p.Q2132H	DO24920	LUAD	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.Q2132H	DO41020	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.N1080I	DO23557	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1667
p.P2810H	DO23556	LUAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7694
p.D2801Y	DO26072	LUAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1944
p.Q3132L	DO25010	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.1944
p.Q2134K	DO25020	LUAD	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation altering degron motif	0.6944
p.Q2132E	DO230965	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.Q2132E	DO224599	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.E2131K	DO231132	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.2778
p.E2131K	DO42817	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.2778
p.V2146I	DO231207	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1389
p.P2394L	DO26993	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.25
p.D2123E	DO26886	LUSC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.0556
p.P1063L	DO26522	LUSC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7582
p.P3122T	DO26466	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.3056
p.P3124S	DO26444	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation altering degron motif	0.5641
p.T2399N	DO27334	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.S3447T	DO27247	LUSC	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.25
p.A1062T	DO219133	LUSC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7139
p.A1062T	DO46957	RECA	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7139
p.P2806R	DO27652	LUSC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7512
p.F2819C	DO220878	MELA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.V2814I	DO220882	MELA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.3056
p.EV2813EI	DO220882	MELA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7454
p.G384E	DO220889	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.N3449S	DO222363	MELA	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.3056
p.N1067S	DO222395	MELA	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.5958
p.G2398D	DO222514	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1389
p.G2398D	COR-L95	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1389
p.S3444L	DO222714	MELA	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.1667
p.Q1055H	DO51965	PRAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1667
p.P2804S	DO219241	PRAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.2778
p.E519G	DO233351	RECA	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1667
p.S512F	DO229459	SKCA	ICGC	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.7982
p.L1068F	DO47590	SKCM	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.587
p.R1052Q	DO51254	SKCM	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0833
p.R1052Q	DO219450	SKCM	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0833
p.P2383S	DO51256	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2222
p.P3123T	DO38727	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation altering degron motif	0.7031
p.S2393Y	DO47769	STAD	ICGC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.2778
p.P3450H	DO39886	THCA	ICGC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation altering degron motif	0.7694
p.F1072L	DO42033	UCEC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.587
p.K2818N	DO43186	UCEC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation substituting flanking lysine	0.3056
p.R1052W	DO41758	UCEC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0833
p.R1052W	CESS	haematopoietic and lymphoid tissue	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.0833
p.N3137S	DO41235	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.L2142I	DO41235	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.25
p.S2140Y	DO42793	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.3056
p.N2126T	DO42713	UCEC	ICGC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation substituting flanking lysine	0.25
p.P3119T	SIDM00338	Acute Myeloid Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00353	Other Sarcomas	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00371	Pancreatic Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00584	Osteosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00465	Ovarian Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00573	Glioblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01181	Hepatocellular Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00687	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00562	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00997	Thyroid Gland Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00988	Kidney Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00793	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00560	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00045	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00359	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00531	Pancreatic Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00168	Head and Neck Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01781	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01611	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01690	Plasma Cell Myeloma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01658	Unknown	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM01451	Pancreatic Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.P3119T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.L3450F	SIDM00216	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation altering degron motif	0.6981
p.L3450F	ACH-000989	Colon/Colorectal Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation altering degron motif	0.6981
p.L3450F	SNU-175	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation altering degron motif	0.6981
p.S429L	SIDM00545	Melanoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1389
p.S429L	ACH-000987	Skin Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1389
p.S429L	Mewo	skin	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1389
p.P376Q	SIDM00845	Burkitt's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P376Q	SIDM00461	Acute Myeloid Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P376Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P376Q	SIDM01519	Head and Neck Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P376Q	ACH-000786	Lymphoma	CCLE	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.P376Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.Q400H	SIDM00845	Burkitt's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.Q400H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.Q400H	Daudi	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0556
p.S428L	SIDM00845	Burkitt's Lymphoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.S428L	SIDM00461	Acute Myeloid Leukemia	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.S428L	SIDM01519	Head and Neck Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.S428L	ACH-000786	Lymphoma	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.S428L	ACH-000992	Head and Neck Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.S428L	Daudi	haematopoietic and lymphoid tissue	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1667
p.I3456L	SIDM00845	Burkitt's Lymphoma	GDSC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.2778
p.S2382N	SIDM00454	Rhabdomyosarcoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1944
p.A2381T	SIDM00496	Thyroid Gland Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation substituting flanking lysine	0.2778
p.A2381T	HTC-C3	thyroid	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation substituting flanking lysine	0.2778
p.G2819E	SIDM01175	Other Sarcomas	GDSC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.G2819E	ACH-002309	Sarcoma	CCLE	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.G2819E	SW684	soft tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.1667
p.A2146V	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1389
p.A2146V	ACH-000647	Esophageal Cancer	CCLE	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1389
p.A2146V	TE-1	oesophagus	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.1389
p.V416L	SIDM00660	Colorectal Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.5654
p.V416L	ACH-000985	Colon/Colorectal Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.5654
p.V416L	LS-411N	large intestine	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.5654
p.A2813T	SIDM00660	Colorectal Carcinoma	GDSC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7139
p.A2813T	ACH-000985	Colon/Colorectal Cancer	CCLE	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7139
p.A2813T	LS-411N	large intestine	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7139
p.G3458R	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.2222
p.G3137R	SIDM01186	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.G3137R	ACH-000554	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.G3137R	UACC-893	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.G3137V	SIDM01186	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.G3137V	ACH-000554	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.G3137V	UACC-893	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0556
p.P2379T	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379T	ACH-000434	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379T	NCI-H1915	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379L	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379L	ACH-000434	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379L	NCI-H1915	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.Q1064L	SIDM01118	Small Cell Lung Carcinoma	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7765
p.Q1064L	ACH-002175	Lung Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7765
p.Q1064L	NCI-H740	lung	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7765
p.S2805T	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation rewiring degron network	0.3056
p.K2401N	SIDM00898	Breast Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.0556
p.K2401N	ACH-000248	Breast Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.0556
p.K2401N	AU565	breast	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.0556
p.P419L	SIDM00097	Breast Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7582
p.P419L	ACH-000147	Breast Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7582
p.P419L	T47D	breast	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation altering degron motif	0.7582
p.P2379R	SIDM00685	Glioblastoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379R	ACH-000819	Brain Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.P2379R	LN-18	central nervous system	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.C3449G	SIDM00217	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.3056
p.C3449G	ACH-000999	Colon/Colorectal Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.3056
p.C3449G	SNU-1040	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.3056
p.S2382R	SIDM00554	Ovarian Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1944
p.S2382R	ACH-000524	Ovarian Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1944
p.S2382R	KURAMOCHI	ovary	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1944
p.K1059N	SIDM00531	Pancreatic Carcinoma	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2778
p.K1059N	ACH-000213	Pancreatic Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2778
p.K1059N	HuP-T4	pancreas	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2778
p.A377T	SIDM00192	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.0833
p.A392V	SIDM01412	Oral Cavity Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.A392V	ACH-000762	Head and Neck Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.G410V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1944
p.G410V	ACH-000845	Lung Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1944
p.A2813P	ACH-000135	Non-Cancerous	CCLE	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7503
p.L3462R	ACH-000436	Myeloma	CCLE	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.1111
p.K1059E	ACH-000961	Endometrial/Uterine Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2778
p.F2123I	ACH-001111	Lymphoma	CCLE	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.0556
p.H427Y	ACH-001148	Lymphoma	CCLE	VVNTPITS	DEG_SCF_FBW7_1	415:422	Mutation rewiring degron network	0.1944
p.S508Y	ACH-001390	Breast Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation blocking phosphorylation signal	0.75
p.I518V	ACH-001853	Bile Duct Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1944
p.H1071L	ACH-002027	Endometrial/Uterine Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.7313
p.E3459K	EVSA-T	breast	COSMIC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.1944
p.S3118L	DB	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.1944
p.T2399P	OVK-18	ovary	COSMIC	ASTSS	DEG_SPOP_SBC_1	2387:2391	Mutation rewiring degron network	0.1111
p.S3119C	SW48	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.2222
p.E2130K	HCC-78	lung	COSMIC	RNTLFKE	LIG_APCC_ABBAyCdc20_2	2133:2139	Mutation rewiring degron network	0.25
p.P2809L	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	2806:2813	Mutation altering degron motif	0.7582
p.L1082F	5637	urinary tract	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.1111
p.G1060D	U-118-MG	central nervous system	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.3056
p.T3114N	MDA-MB-436	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	3123:3127	Mutation rewiring degron network	0.0833
p.A3457G	NUGC-3	stomach	COSMIC	PNTTS	DEG_SPOP_SBC_1	3450:3454	Mutation rewiring degron network	0.25
p.P1078S	KALS-1	central nervous system	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation rewiring degron network	0.2222
p.L1062V	LN-229	central nervous system	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	1061:1074	Mutation altering degron motif	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFHX4

UniProt ID: Q86UP3

Entrez ID: 79776

Protein name: Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFHX4 in