DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_SPOP_SBC_1

Location: 3450:3454

E3 ligase: SPOP

DEGRON score: 0.7986

ASA_SCORE: 89.2

COIL: 0.9358

CONS_SCORE: 0.2829

DSS_SCORE: 0.5666

HELIX: 0.0392

FCONS_SCORE: 0.966

RIG_SCORE: 0.5909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3450I	TCGA-44-5644	LUAD	TCGA	PNTTS	DEG_SPOP_SBC_1	0.7174
p.L3450I	TCGA-AP-A0LM	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.7174
p.A3455D	TCGA-A5-A0G1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.3056
p.P3443S	TCGA-EE-A2GB	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	0.1389
p.G3458W	TCGA-GN-A26C	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	0.2222
p.P3443A	TCGA-O2-A52N	LUSC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.1389
p.S3456L	DO222884	COCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.S3456L	DO228142	PBCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.S3456L	DO50075	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.N3463S	DO228631	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.0833
p.S3447T	DO27247	LUSC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.25
p.N3449S	DO222363	MELA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.3056
p.S3444L	DO222714	MELA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.1667
p.P3450H	DO39886	THCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.7694
p.L3450F	SIDM00216	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.6981
p.L3450F	ACH-000989	Colon/Colorectal Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	0.6981
p.L3450F	SNU-175	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.6981
p.I3456L	SIDM00845	Burkitt's Lymphoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.G3458R	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.2222
p.C3449G	SIDM00217	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.3056
p.C3449G	ACH-000999	Colon/Colorectal Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	0.3056
p.C3449G	SNU-1040	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.3056
p.L3462R	ACH-000436	Myeloma	CCLE	PNTTS	DEG_SPOP_SBC_1	0.1111
p.E3459K	EVSA-T	breast	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.1944
p.A3457G	NUGC-3	stomach	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	143:147	PNTTS	SPOP	0.8566	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	432:436	PNTTS	SPOP	0.9996	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	961:965	PNTTS	SPOP	0.9965	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1144:1148	PNTTS	SPOP	0.9567	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3450:3454	PNTTS	SPOP	0.7986	More...
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_SPOP_SBC_1	162:166	PNTTS	SPOP	0.9644	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SPOP_SBC_1	356:360	PNTTS	SPOP	0.9623	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	2442:2446	PNTTS	SPOP	0.6504	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	562:566	PNTTS	SPOP	0.5576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons