DegronMD

Uniprot ID: Q8TF74

Source protein: WAS/WASL-interacting protein family member 2

Source gene: WIPF2

Class: DEG_SPOP_SBC_1

Location: 162:166

E3 ligase: SPOP

DEGRON score: 0.9644

ASA_SCORE: 86.88

COIL: 0.964

CONS_SCORE: 0.4606

DSS_SCORE: 0.8471

HELIX: 0.0196

FCONS_SCORE: 0.6907

RIG_SCORE: 0.5119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T168M	TCGA-3M-AB47	STAD	TCGA	PNTTS	DEG_SPOP_SBC_1	0.2778
p.T168M	TCGA-BP-5198	KIRC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.2778
p.T168M	DO19128	KIRC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.T168M	DO222327	STAD	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R161Q	TCGA-66-2769	LUSC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.3056
p.R161Q	DO26522	LUSC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.3056
p.S174C	TCGA-DH-A7UT	LGG	TCGA	PNTTS	DEG_SPOP_SBC_1	0.5556
p.S174C	DO222830	BTCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.5556
p.S174C	DO51811	LGG	ICGC	PNTTS	DEG_SPOP_SBC_1	0.5556
p.S166N	TCGA-DU-6392	LGG	TCGA	PNTTS	DEG_SPOP_SBC_1	0.7069
p.S166N	DO22237	LGG	ICGC	PNTTS	DEG_SPOP_SBC_1	0.7069
p.G169C	TCGA-EE-A3AA	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	0.25
p.G169C	DO37571	SKCM	ICGC	PNTTS	DEG_SPOP_SBC_1	0.25
p.S175F	TCGA-ZF-AA4X	BLCA	TCGA	PNTTS	DEG_SPOP_SBC_1	0.5278
p.S175F	DO219091	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.5278
p.S173G	DO49342	ALL	ICGC	PNTTS	DEG_SPOP_SBC_1	0.1389
p.R172S	DO8642	COAD	ICGC	PNTTS	DEG_SPOP_SBC_1	0.1667
p.R161S	DO52462	COCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.3056
p.M170T	DO233865	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.2222
p.S173I	DO233903	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.1389
p.R169L	DO232761	PBCA	ICGC	PNTTS	DEG_SPOP_SBC_1	0.25
p.R172H	EW-11	bone	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.1667
p.P176H	CCK-81	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	143:147	PNTTS	SPOP	0.8566	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	432:436	PNTTS	SPOP	0.9996	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	961:965	PNTTS	SPOP	0.9965	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1144:1148	PNTTS	SPOP	0.9567	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3450:3454	PNTTS	SPOP	0.7986	More...
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_SPOP_SBC_1	162:166	PNTTS	SPOP	0.9644	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SPOP_SBC_1	356:360	PNTTS	SPOP	0.9623	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	2442:2446	PNTTS	SPOP	0.6504	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	562:566	PNTTS	SPOP	0.5576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons