DegronMD - Q9UPV9(TRAK1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V458I	TCGA-17-Z031	LUAD	TCGA	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0556
p.V458I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0556
p.V458I	ACH-000937	Leukemia	CCLE	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0556
p.V458I	PF-382	haematopoietic and lymphoid tissue	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0556
p.S535I	TCGA-67-3774	LUAD	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.25
p.R534H	TCGA-A5-A1OF	UCEC	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.2222
p.V777A	TCGA-A5-A1OF	UCEC	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.3056
p.V777A	TCGA-A5-A1OF	UCEC	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.0833
p.V777A	DO42568	UCEC	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.3056
p.V777A	DO42568	UCEC	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.0833
p.S770A	TCGA-AA-3663	COAD	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1111
p.S770A	DO9346	COAD	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1111
p.T707M	TCGA-AA-3947	COAD	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.T707M	TCGA-AJ-A3BH	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.T707M	DO8192	COAD	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.T707M	DO41638	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.S803G	TCGA-AP-A051	UCEC	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.0556
p.S803G	DO42673	UCEC	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.0556
p.I778L	TCGA-B5-A11E	UCEC	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.6063
p.I778L	DO41644	UCEC	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.6063
p.P782S	TCGA-BF-A3DM	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.6752
p.P782S	DO222363	MELA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.6752
p.P782S	DO48667	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.6752
p.K945T	TCGA-CD-A48C	STAD	TCGA	SLR	DEG_APCC_TPR_1	951:953	Mutation substituting flanking lysine	0.2778
p.K945T	DO47912	STAD	ICGC	SLR	DEG_APCC_TPR_1	951:953	Mutation substituting flanking lysine	0.2778
p.R552H	TCGA-CD-A4MJ	STAD	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.R534C	TCGA-CM-5349	COAD	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.2222
p.S702N	TCGA-D1-A17K	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.S702N	DO42937	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.P782Q	TCGA-EE-A183	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7035
p.P782Q	DO37715	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7035
p.H364N	TCGA-EE-A29E	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.S785L	TCGA-EE-A2GI	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7667
p.S785L	DO37410	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7667
p.S792F	TCGA-EE-A2MS	SKCM	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6871
p.S792F	TCGA-Z2-A8RT	SKCM	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6871
p.S792F	DO37567	SKCM	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6871
p.S792F	DO51301	SKCM	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6871
p.P708L	TCGA-EO-A22U	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.7582
p.P708L	DO43755	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.7582
p.M355I	TCGA-G3-AAV7	LIHC	TCGA	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.3056
p.S537F	TCGA-GN-A263	SKCM	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.3056
p.L547P	TCGA-GV-A3QF	BLCA	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.2222
p.R362C	TCGA-IB-7651	PAAD	TCGA	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.R362C	SIDM01169	Ovarian Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.R362C	SIDM00216	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.R362C	TOV-21G	ovary	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.R362C	SNU-175	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.E542K	TCGA-LN-A7HV	ESCA	TCGA	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation altering degron motif	0.591
p.E542K	SIDM02042	Pancreatic Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation altering degron motif	0.591
p.P370S	TCGA-QS-A8F1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0556
p.R953Q	DO1170	BRCA	ICGC	SLR	DEG_APCC_TPR_1	951:953	Mutation altering degron motif	0.7329
p.D436N	DO8264	COAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.S541T	DO227987	COCA	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation altering degron motif	0.7116
p.M775I	DO227880	COCA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.25
p.W552R	DO234184	ESAD	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.R545H	DO234292	ESAD	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.2778
p.A440V	DO233731	GACA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.2778
p.A440V	DO38328	STAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.2778
p.M365V	DO14470	HNSC	ICGC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1944
p.R448L	DO228944	LICA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.8428
p.T772M	DO228946	LICA	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1667
p.T772M	DO230550	LUSC	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1667
p.A721S	DO229019	LICA	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.0556
p.A944S	DO229025	LICA	ICGC	SLR	DEG_APCC_TPR_1	951:953	Mutation rewiring degron network	0.1389
p.C801F	DO229046	LICA	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.1111
p.S719I	DO229006	LICA	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation blocking phosphorylation signal	0.5556
p.A944G	DO50884	LICA	ICGC	SLR	DEG_APCC_TPR_1	951:953	Mutation rewiring degron network	0.1389
p.D546Y	DO45431	LUSC	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.25
p.S796F	DO220854	MELA	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.25
p.K945Q	DO46468	OV	ICGC	SLR	DEG_APCC_TPR_1	951:953	Mutation substituting flanking lysine	0.2778
p.R448Q	DO51511	PACA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7329
p.R448Q	DO219776	UCEC	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7329
p.L536F	DO51298	SKCM	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.2778
p.R443W	DO47889	STAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.8634
p.E454D	DO229275	THCA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.R550H	DO52399	UCEC	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1389
p.A533V	DO42512	UCEC	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1944
p.C551R	DO41133	UCEC	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1111
p.S363Y	DO42793	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.25
p.A528V	SIDM01237	Hepatocellular Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0556
p.A528V	C3A	liver	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0556
p.M787V	SIDM01652	Non-Cancerous	GDSC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6097
p.M787V	SIDM00187	Kidney Carcinoma	GDSC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6097
p.M787V	ACH-002352	Non-Cancerous	CCLE	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation altering degron motif	0.6097
p.P549L	SIDM00705	Non-Cancerous	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1667
p.H550D	SIDM00139	Mesothelioma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1389
p.H550D	NCI-H226	lung	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1389
p.M775V	SIDM00803	Kidney Carcinoma	GDSC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.25
p.M775V	ACH-000411	Kidney Cancer	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.25
p.M775V	769-P	kidney	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.25
p.G451C	SIDM00014	Colorectal Carcinoma	GDSC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.25
p.G451C	LIM1215	large intestine	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.25
p.Y771C	SIDM00487	Colorectal Carcinoma	GDSC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1389
p.Y771C	ACH-000963	Colon/Colorectal Cancer	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1389
p.Y771C	CCK-81	large intestine	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.1389
p.R362H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.R362H	NCI-H650	lung	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.L347P	SIDM01147	Gastric Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0833
p.L347P	NCI-N87	stomach	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0833
p.R552C	SIDM00368	Small Cell Lung Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.R552C	SBC-5	lung	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.V442F	SIDM00954	Breast Carcinoma	GDSC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7068
p.V442F	COLO-824	breast	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7068
p.W552C	SIDM00996	Thyroid Gland Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.W552C	SIDM00575	Glioma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.W552C	8505C	thyroid	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.W552C	NMC-G1	central nervous system	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.I454M	SIDM00363	Acute Myeloid Leukemia	GDSC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.I454M	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.S702R	SIDM00515	Melanoma	GDSC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.S702R	ACH-000401	Skin Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.S702R	ACH-001339	Skin Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.S702R	COLO-800	skin	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.T549M	SIDM01608	Endometrial Carcinoma	GDSC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1667
p.C713R	ACH-000373	Leukemia	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.C713R	ACH-000452	Esophageal Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.V709L	ACH-000950	Colon/Colorectal Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.5654
p.A454V	ACH-001021	Liver Cancer	CCLE	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.A454V	C3A	liver	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.V709A	ACH-001786	Colon/Colorectal Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.5825
p.V368F	ACH-001820	Breast Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.V368F	COLO-824	breast	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.P795S	ACH-001970	Metastasis	CCLE	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.0556
p.P795S	ACH-001970	Metastasis	CCLE	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.2778
p.S361G	PCI-30	upper aerodigestive tract	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.3056
p.H446D	NCI-H226	lung	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7688
p.R537C	BFTC-905	urinary tract	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.3056
p.R448C	SBC-5	lung	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.8301
p.V354I	PF-382	haematopoietic and lymphoid tissue	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.A368V	HEC-1	endometrium	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.A539V	CMK	haematopoietic and lymphoid tissue	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation altering degron motif	0.6936
p.P774L	IM-9	haematopoietic and lymphoid tissue	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation substituting flanking lysine	0.3333
p.T529I	LS-411N	large intestine	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.0833
p.A535V	SNU-1040	large intestine	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.25
p.I350M	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1667
p.G705S	OVMIU	ovary	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.6993
p.P776L	NCI-H1563	lung	COSMIC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation rewiring degron network	0.2778
p.P776L	NCI-H1563	lung	COSMIC	PMQTPTSS	DEG_SCF_FBW7_1	786:793	Mutation rewiring degron network	0.0556
p.I362V	U-2-OS	bone	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.M717V	769-P	kidney	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.1667
p.R706Q	SCC-9	upper aerodigestive tract	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.7329
p.Y713C	CCK-81	large intestine	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.2778
p.G347C	LIM1215	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0833
p.A551V	KGN	ovary	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.1111
p.S534Y	BL-70	haematopoietic and lymphoid tissue	COSMIC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation rewiring degron network	0.2222
p.A694V	SK-MEL-2	skin	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRAK1

UniProt ID: Q9UPV9

Entrez ID: 22906

Protein name: Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRAK1 in