DegronMD - Q9UPV9(TRAK1)

FUNCTION: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitocho... View more >>

GO - Biological processes (BP): anterograde axonal transport of mitochondrion [GO:0098957]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [... View more >>

GO - Molecular function (MF): GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]

GO - Cellular component (CC): axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
SLR	DEG_APCC_TPR_1	APC,CDC20,FZR1	Trafficking kinesin-binding protein 1	951:953	More..
VSTPRSS	DEG_SCF_FBW7_1	FBXW7	Trafficking kinesin-binding protein 1	442:448	More..
LTPTES	DEG_SCF_FBW7_1	FBXW7	Trafficking kinesin-binding protein 1	538:543	More..
LKSTPVAT	DEG_SCF_FBW7_1	FBXW7	Trafficking kinesin-binding protein 1	704:711	More..
IPSTPPNS	DEG_SCF_FBW7_1	FBXW7	Trafficking kinesin-binding protein 1	778:785	More..
PMQTPTSS	DEG_SCF_FBW7_1	FBXW7	Trafficking kinesin-binding protein 1	786:793	More..
PNTTS	DEG_SPOP_SBC_1	SPOP	Trafficking kinesin-binding protein 1	356:360	More..

Showing 1 to 7 of 7 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R443W	DO47889	STAD	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.8634
p.T707M	TCGA-AA-3947	COAD	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.T707M	TCGA-AJ-A3BH	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.T707M	DO8192	COAD	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.T707M	DO41638	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.8534
p.R448L	DO228944	LICA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.8428
p.R448C	SBC-5	lung	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.8301
p.H446D	NCI-H226	lung	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7688
p.S785L	TCGA-EE-A2GI	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7667
p.S785L	DO37410	SKCM	ICGC	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7667
p.P708L	TCGA-EO-A22U	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.7582
p.P708L	DO43755	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.7582
p.R953Q	DO1170	BRCA	ICGC	SLR	DEG_APCC_TPR_1	951:953	Mutation altering degron motif	0.7329
p.R448Q	DO51511	PACA	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7329
p.R448Q	DO219776	UCEC	ICGC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7329
p.R706Q	SCC-9	upper aerodigestive tract	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	704:711	Mutation altering degron motif	0.7329
p.S541T	DO227987	COCA	ICGC	LTPTES	DEG_SCF_FBW7_1	538:543	Mutation altering degron motif	0.7116
p.V442F	SIDM00954	Breast Carcinoma	GDSC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7068
p.V442F	COLO-824	breast	COSMIC	VSTPRSS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7068
p.P782Q	TCGA-EE-A183	SKCM	TCGA	IPSTPPNS	DEG_SCF_FBW7_1	778:785	Mutation altering degron motif	0.7035

Showing 1 to 20 of 147 entries

Previous1 2 3 4 5…8Next

No resistance data available for this Degron.

Kaplan plot for TRAK1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRAK1

UniProt ID: Q9UPV9

Entrez ID: 22906

Protein name: Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No resistance data available for this Degron.

Kaplan plot for TRAK1 in