DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_SPOP_SBC_1

Location: 356:360

E3 ligase: SPOP

DEGRON score: 0.9623

ASA_SCORE: 79.32

COIL: 0.8844

CONS_SCORE: 0.3705

DSS_SCORE: 0.4778

HELIX: 0.0734

FCONS_SCORE: 0.842

RIG_SCORE: 0.6844

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M355I	TCGA-G3-AAV7	LIHC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.3056
p.S361G	PCI-30	upper_aerodigestive_tract	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.3056
p.R362C	TCGA-IB-7651	PAAD	TCGA	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R362C	SIDM01169	Ovarian Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R362C	SIDM00216	Colorectal Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R362C	TOV-21G	ovary	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R362C	SNU-175	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R362H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.R362H	NCI-H650	lung	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.V354I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.I362V	U-2-OS	bone	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.2778
p.S363Y	DO42793	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.25
p.H364N	TCGA-EE-A29E	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	0.2222
p.M365V	DO14470	HNSC	ICGC	PNTTS	DEG_SPOP_SBC_1	0.1944
p.I350M	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.1667
p.V368F	ACH-001820	Breast Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	0.1111
p.V368F	COLO-824	breast	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.1111
p.A368V	HEC-1	endometrium	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.1111
p.L347P	SIDM01147	Gastric Carcinoma	GDSC	PNTTS	DEG_SPOP_SBC_1	0.0833
p.L347P	NCI-N87	stomach	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.0833
p.G347C	LIM1215	large_intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	0.0833
p.P370S	TCGA-QS-A8F1	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	2442:2446	PNTTS	SPOP	0.6504	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	961:965	PNTTS	SPOP	0.9965	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1144:1148	PNTTS	SPOP	0.9567	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	143:147	PNTTS	SPOP	0.8566	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	562:566	PNTTS	SPOP	0.5576	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SPOP_SBC_1	356:360	PNTTS	SPOP	0.9623	More...
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_SPOP_SBC_1	162:166	PNTTS	SPOP	0.9644	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	432:436	PNTTS	SPOP	0.9996	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3450:3454	PNTTS	SPOP	0.7986	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons