DegronMD - Q8TF74(WIPF2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T168M	TCGA-3M-AB47	STAD	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1111
p.T168M	TCGA-3M-AB47	STAD	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.T168M	TCGA-BP-5198	KIRC	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1111
p.T168M	TCGA-BP-5198	KIRC	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.T168M	DO19128	KIRC	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1111
p.T168M	DO19128	KIRC	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.T168M	DO222327	STAD	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1111
p.T168M	DO222327	STAD	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.P437S	TCGA-61-1728	OV	TCGA	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.3056
p.R161Q	TCGA-66-2769	LUSC	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.3056
p.R161Q	TCGA-66-2769	LUSC	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.R161Q	DO26522	LUSC	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.3056
p.R161Q	DO26522	LUSC	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.A143S	TCGA-69-A59K	LUAD	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6477
p.A143S	DO45335	LUAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6477
p.G350W	TCGA-85-6561	LUSC	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.2222
p.R256H	TCGA-A5-A0G2	UCEC	TCGA	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.R256H	DO41235	UCEC	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.A249S	TCGA-A5-A1OF	UCEC	TCGA	PPPY	ITCH	252:255	Mutation rewiring degron network	0.25
p.A249S	DO42568	UCEC	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.25
p.D137N	TCGA-AA-3492	COAD	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2222
p.D137N	DO8224	COAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2222
p.R430S	TCGA-AA-A01P	COAD	TCGA	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.1111
p.P251T	TCGA-BH-A18P	BRCA	TCGA	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.P251T	DO3346	BRCA	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.R333Q	TCGA-CA-6718	COAD	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.0556
p.P436Q	TCGA-CD-8529	STAD	TCGA	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.2778
p.D407G	TCGA-CM-5341	COAD	TCGA	DDFESKYSFHP	CBL_PTK	394:404	Mutation rewiring degron network	0.25
p.K399N	TCGA-CV-6952	HNSC	TCGA	DDFESKYSFHP	CBL_PTK	394:404	Mutation altering degron motif	0.5806
p.V405I	TCGA-D7-6822	STAD	TCGA	DDFESKYSFHP	CBL_PTK	394:404	Mutation rewiring degron network	0.3056
p.T138I	TCGA-DA-A1HV	SKCM	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.25
p.T138I	DO37659	SKCM	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.25
p.S174C	TCGA-DH-A7UT	LGG	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.5556
p.S174C	DO222830	BTCA	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.5556
p.S174C	DO51811	LGG	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.5556
p.P252T	TCGA-DK-A1AC	BLCA	TCGA	PPPY	ITCH	252:255	Mutation altering degron motif	0.7031
p.P252T	DO514	BLCA	ICGC	PPPY	ITCH	252:255	Mutation altering degron motif	0.7031
p.P252T	DO50387	ESAD	ICGC	PPPY	ITCH	252:255	Mutation altering degron motif	0.7031
p.S166N	TCGA-DU-6392	LGG	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7069
p.S166N	DO22237	LGG	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7069
p.R347Q	TCGA-E6-A1LX	UCEC	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.3056
p.R347Q	TCGA-IB-7651	PAAD	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.3056
p.L439F	TCGA-EE-A29L	SKCM	TCGA	ILR	DEG_APCC_TPR_1	438:440	Mutation altering degron motif	0.6981
p.P146S	TCGA-EE-A2GO	SKCM	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5641
p.P146S	DO37823	SKCM	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5641
p.G169C	TCGA-EE-A3AA	SKCM	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.G169C	TCGA-EE-A3AA	SKCM	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.G169C	DO37571	SKCM	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.G169C	DO37571	SKCM	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.P341S	TCGA-EE-A3AD	SKCM	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.2778
p.P342S	TCGA-ER-A19D	SKCM	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.3056
p.R133H	TCGA-EY-A548	UCEC	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R133H	TCGA-F7-A623	HNSC	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R133H	DO44443	HNSC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R133H	DO48173	UCEC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R133C	TCGA-FI-A2D5	UCEC	TCGA	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R133C	DO41331	UCEC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.S160C	TCGA-G2-AA3B	BLCA	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.643
p.S160C	DO51882	BLCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.643
p.R356Q	TCGA-GD-A76B	BLCA	TCGA	PPPY	ITCH	343:346	Mutation rewiring degron network	0.0556
p.D394Y	TCGA-OR-A5KB	ACC	TCGA	DDFESKYSFHP	CBL_PTK	394:404	Mutation altering degron motif	0.7325
p.Y414C	TCGA-P3-A6SX	HNSC	TCGA	DDFESKYSFHP	CBL_PTK	394:404	Mutation blocking phosphorylation signal	0.5
p.D394N	TCGA-QS-A5YR	UCEC	TCGA	DDFESKYSFHP	CBL_PTK	394:404	Mutation altering degron motif	0.5821
p.R256L	TCGA-XF-A9T3	BLCA	TCGA	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.R256L	DO51922	BLCA	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.R256L	DO229029	LICA	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.S175F	TCGA-ZF-AA4X	BLCA	TCGA	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.5278
p.S175F	DO219091	BLCA	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation blocking phosphorylation signal	0.5278
p.S173G	DO49342	ALL	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389
p.F150C	DO6685	CLLE	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.3056
p.F150C	DO6685	CLLE	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2778
p.D149G	DO10060	COAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7198
p.S141N	DO8858	COAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5958
p.R172S	DO8642	COAD	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.R132W	DO230326	COCA	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R161S	DO52462	COCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.3056
p.R161S	DO52462	COCA	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.S247C	DO50387	ESAD	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.P251S	DO223024	ESCA	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.M170T	DO233865	GACA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0556
p.M170T	DO233865	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.S173I	DO233903	GACA	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389
p.Y156C	DO49051	HNSC	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7087
p.Y156C	DO45187	LIRI	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7087
p.K141N	DO14240	HNSC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6918
p.S141I	DO228948	LICA	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.623
p.A152S	DO229028	LICA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7588
p.G132W	DO229022	LICA	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.G260V	DO229027	LICA	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.V131L	DO50776	LIRI	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0556
p.R150Q	DO229244	LMS	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.3056
p.R150Q	DO229244	LMS	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2778
p.R169L	DO232761	PBCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.R169L	DO232761	PBCA	ICGC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.P251L	DO47100	RECA	ICGC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.P153L	DO218874	SKCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7582
p.V147I	DO38423	STAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7076
p.D136N	DO50081	UCEC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1944
p.P157L	SIDM00216	Colorectal Carcinoma	GDSC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.6471
p.P157L	ACH-000989	Colon/Colorectal Cancer	CCLE	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.6471
p.P157L	SNU-175	large intestine	COSMIC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.6471
p.A249V	SIDM00967	Ovarian Carcinoma	GDSC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.25
p.A249V	SIDM00068	Colorectal Carcinoma	GDSC	PPPY	ITCH	252:255	Mutation rewiring degron network	0.25
p.S385C	SIDM00789	Colorectal Carcinoma	GDSC	DDFESKYSFHP	CBL_PTK	394:404	Mutation blocking phosphorylation signal	0.5278
p.S385C	ACH-000997	Colon/Colorectal Cancer	CCLE	DDFESKYSFHP	CBL_PTK	394:404	Mutation blocking phosphorylation signal	0.5278
p.S385C	ACH-001061	Colon/Colorectal Cancer	CCLE	DDFESKYSFHP	CBL_PTK	394:404	Mutation blocking phosphorylation signal	0.5278
p.S385C	HCT-15	large intestine	COSMIC	DDFESKYSFHP	CBL_PTK	394:404	Mutation blocking phosphorylation signal	0.5278
p.S351L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	343:346	Mutation rewiring degron network	0.1944
p.S351L	ACH-002256	Leukemia	CCLE	PPPY	ITCH	343:346	Mutation rewiring degron network	0.1944
p.S351L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	343:346	Mutation rewiring degron network	0.1944
p.R430H	SIDM00203	Ewing's Sarcoma	GDSC	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.1111
p.R430H	ACH-002111	Bone Cancer	CCLE	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.1111
p.R430H	EW-11	bone	COSMIC	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.1111
p.P434H	SIDM00487	Colorectal Carcinoma	GDSC	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.2222
p.P434H	ACH-000963	Colon/Colorectal Cancer	CCLE	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.2222
p.P434H	CCK-81	large intestine	COSMIC	ILR	DEG_APCC_TPR_1	438:440	Mutation rewiring degron network	0.2222
p.L159P	SIDM00844	Burkitt's Lymphoma	GDSC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7582
p.L159P	ACH-000654	Lymphoma	CCLE	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7582
p.L159P	Raji	haematopoietic and lymphoid tissue	COSMIC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7582
p.S160F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.6871
p.S160F	ACH-001127	Leukemia	CCLE	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.6871
p.S160F	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	QRPSLPDLS	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.6871
p.D395H	ACH-000033	Lung Cancer	CCLE	DDFESKYSFHP	CBL_PTK	394:404	Mutation altering degron motif	0.6577
p.P253L	ACH-001289	Rhabdoid	CCLE	PPPY	ITCH	252:255	Mutation altering degron motif	0.7582
p.R172H	EW-11	bone	COSMIC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.P176H	CCK-81	large intestine	COSMIC	PNTTS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WIPF2

UniProt ID: Q8TF74

Entrez ID: 147179

Protein name: WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WIPF2 in