DegronMD

Uniprot ID: Q8TF74

Source protein: WAS/WASL-interacting protein family member 2

Source gene: WIPF2

Class: DEG_APCC_DBOX_1

Location: 152:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 95.0667

COIL: 0.9508

CONS_SCORE: 0.6834

DSS_SCORE: 0.8466

HELIX: 0.0326

FCONS_SCORE: 1.3252

RIG_SCORE: 0.5838

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T168M	TCGA-3M-AB47	STAD	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	0.1111
p.T168M	TCGA-BP-5198	KIRC	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	0.1111
p.T168M	DO19128	KIRC	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.1111
p.T168M	DO222327	STAD	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.1111
p.R161Q	TCGA-66-2769	LUSC	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	0.3056
p.R161Q	DO26522	LUSC	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.3056
p.G169C	TCGA-EE-A3AA	SKCM	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	0.0833
p.G169C	DO37571	SKCM	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.0833
p.S160C	TCGA-G2-AA3B	BLCA	TCGA	QRPSLPDLS	DEG_APCC_DBOX_1	0.643
p.S160C	DO51882	BLCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.643
p.F150C	DO6685	CLLE	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.2778
p.R161S	DO52462	COCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.3056
p.M170T	DO233865	GACA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.0556
p.Y156C	DO49051	HNSC	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.7087
p.Y156C	DO45187	LIRI	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.7087
p.A152S	DO229028	LICA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.7588
p.R150Q	DO229244	LMS	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.2778
p.R169L	DO232761	PBCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.0833
p.P153L	DO218874	SKCA	ICGC	QRPSLPDLS	DEG_APCC_DBOX_1	0.7582
p.P157L	SIDM00216	Colorectal Carcinoma	GDSC	QRPSLPDLS	DEG_APCC_DBOX_1	0.6471
p.P157L	ACH-000989	Colon/Colorectal Cancer	CCLE	QRPSLPDLS	DEG_APCC_DBOX_1	0.6471
p.P157L	SNU-175	large_intestine	COSMIC	QRPSLPDLS	DEG_APCC_DBOX_1	0.6471
p.L159P	SIDM00844	Burkitt's Lymphoma	GDSC	QRPSLPDLS	DEG_APCC_DBOX_1	0.7582
p.L159P	ACH-000654	Lymphoma	CCLE	QRPSLPDLS	DEG_APCC_DBOX_1	0.7582
p.L159P	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	QRPSLPDLS	DEG_APCC_DBOX_1	0.7582
p.S160F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	QRPSLPDLS	DEG_APCC_DBOX_1	0.6871
p.S160F	ACH-001127	Leukemia	CCLE	QRPSLPDLS	DEG_APCC_DBOX_1	0.6871
p.S160F	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	QRPSLPDLS	DEG_APCC_DBOX_1	0.6871

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRPSLPDLS

Degron related mutations and impact score

Drug responses associated with WIPF2 mutations

All proteins holding degron of QRPSLPDLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_APCC_DBOX_1	152:160	QRPSLPDLS	APC,CDC20,FZR1	0.9953	More...