DegronMD

Uniprot ID: Q8TF74

Source protein: WAS/WASL-interacting protein family member 2

Source gene: WIPF2

Class: DEG_APCC_DBOX_1

Location: 141:149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8188

ASA_SCORE: 84.1

COIL: 0.8963

CONS_SCORE: 0.4889

DSS_SCORE: 0.8481

HELIX: 0.0863

FCONS_SCORE: 0.9614

RIG_SCORE: 0.6181

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A143S	TCGA-69-A59K	LUAD	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.6477
p.A143S	DO45335	LUAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.6477
p.D137N	TCGA-AA-3492	COAD	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.2222
p.D137N	DO8224	COAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.2222
p.T138I	TCGA-DA-A1HV	SKCM	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.25
p.T138I	DO37659	SKCM	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.25
p.P146S	TCGA-EE-A2GO	SKCM	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.5641
p.P146S	DO37823	SKCM	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.5641
p.R133H	TCGA-EY-A548	UCEC	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.1111
p.R133H	TCGA-F7-A623	HNSC	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.1111
p.R133H	DO44443	HNSC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.1111
p.R133H	DO48173	UCEC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.1111
p.R133C	TCGA-FI-A2D5	UCEC	TCGA	SRASLPELP	DEG_APCC_DBOX_1	0.1111
p.R133C	DO41331	UCEC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.1111
p.F150C	DO6685	CLLE	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.3056
p.D149G	DO10060	COAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.7198
p.S141N	DO8858	COAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.5958
p.R132W	DO230326	COCA	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.0833
p.K141N	DO14240	HNSC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.6918
p.S141I	DO228948	LICA	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.623
p.G132W	DO229022	LICA	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.0833
p.V131L	DO50776	LIRI	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.0556
p.R150Q	DO229244	LMS	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.3056
p.V147I	DO38423	STAD	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.7076
p.D136N	DO50081	UCEC	ICGC	SRASLPELP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF74	WAS/WASL-interacting protein family member 2	DEG_APCC_DBOX_1	141:149	SRASLPELP	APC,CDC20,FZR1	0.8188	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons